Registration Dossier
Registration Dossier
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EC number: 297-566-6 | CAS number: 93642-68-3
Endpoint summary
Administrative data
Description of key information
The key study for acute oral toxicity reports an LD50 of >2000 mg/kg bw, in a reliable study conducted according to OECD TG 401 and in compliance with GLP (Hoechst, 1998).
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The key study for acute oral toxicity was conducted according to OECD TG 401 and in compliance with GLP (Hoechst, 1998). The animals showed impairment of motility and respiration as well as narrowed palpebral fissure. Symptoms were reversible after one day. There were no treatment-related body weight changes or mortalities. Narrowed palpebral fissure was reported but there were no macroscopically visible changes at necropsy. The LD50 was determined to be >2000 mg/kg bw.
Justification for selection of acute toxicity – oral endpoint
The study was conducted according to an appropriate guideline and in compliance with GLP.
Justification for classification or non-classification
Based on the available acute oral toxicity study, no classification is required for the registered substance in accordance with Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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