Registration Dossier
Registration Dossier
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EC number: 217-038-0 | CAS number: 1726-23-4
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian germ cell study: cytogenicity / chromosome aberration
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summary data only available. No details of test method / results. For read across justification see Section 13.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1983
Materials and methods
- Principles of method if other than guideline:
- Guaranteed fertile males were treated by an unspecified route.
- GLP compliance:
- not specified
- Type of assay:
- rodent dominant lethal assay
Test material
- Reference substance name:
- Tris(2-ethylhexyl)trimellitate
- IUPAC Name:
- Tris(2-ethylhexyl)trimellitate
- Details on test material:
- - Molecular formula (if other than submission substance): C33 H54 O6
- Molecular weight (if other than submission substance): 546.79
- Smiles notation (if other than submission substance): c1(c(ccc(c1)C(OC[C@@H](CCCC)CC)=O)C(OC[C@@H](CCCC)CC)=O)C(OC [C@@H](CCCC)CC)=O
- InChl (if other than submission substance): 1S/C33H54O6/c1-7-13-16-25(10-4)22-37-31(34)28-19-20-29(32(35)38-23-26 (11-5)17-14-8-2)30(21-28)33(36)39-24-27(12-6)18-15-9-3/h19-21,25-27H,7-18,22- 24H2,1-6H3
- Structural formula attached as image file (if other than submission substance): see 3319-31-1 structure.png
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- Not included in references above.
Administration / exposure
- Route of administration:
- other: No data
- Vehicle:
- No data
- Details on exposure:
- No data
- Duration of treatment / exposure:
- No data
- Frequency of treatment:
- No data
- Post exposure period:
- No data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1400 mg/kg bw
Basis:
no data
- No. of animals per sex per dose:
- No data
- Positive control(s):
- Yes, METEPA (probably tris(1-(2-methyl)aziridinyl) phosphine oxide)
Examinations
- Tissues and cell types examined:
- No data
- Details of tissue and slide preparation:
- No data
- Evaluation criteria:
- No data
- Statistics:
- No data
Results and discussion
Test results
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- valid
- Additional information on results:
- No data
Any other information on results incl. tables
Results with METEPA confirmed the validity of the system.
TOTM was not mutagenic when compared with the positive control
Applicant's summary and conclusion
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