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Diss Factsheets

Toxicological information

Dermal absorption

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Administrative data

dermal absorption
Type of information:
calculation (if not (Q)SAR)
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Study period:
November 21, 2014
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Estimation by calculation is based on accepted and valid (Q)SAR methods.

Data source

Referenceopen allclose all

Reference Type:
other: software
Reference Type:
study report
Report date:

Materials and methods

Test guideline
other: ECHA Guidance on information requirements and chemical safety assessment - Chapter R.06: QSARs and grouping of chemicals - May 2008
Principles of method if other than guideline:
The rate of mass build-up (or loss) on the skin comes from the deposition rate onto the skin minus the absorption rate into the Stratum Corneum (SC) and the amount evaporating from the skin to the air.

IH Skin Perm provides two primary dermal exposure modes to the modeler. The first is “instantaneous deposition” in which the substance is assumed to be on the skin as the result of a single exposure event. The second is “deposition over time” in which the substance is assumed to be applied at a constant rate over time. In the first case (instantaneous deposition) the above DepositionRate is zero and IH Skin Perm then works to keep track of this single dose over time as it is absorbed into the SC or evaporates from the surface of the skin. In the second case (deposition over time) the rate of the substance going to the skin is assumed constant and the thickness of the film on the skin will either increase or decrease with time depending on the relative rates of deposition and removal.

The user inputs the amount going onto the skin as a single dose or as a constant rate and IH SkinPerm calculates the amount of chemical absorbed into the SC over time until all the material disappears from the surface via absorption and evaporation or the exposure is considered to be over.
Ultimately, the program estimates the amount of chemical absorbed into the systemic circulation of the body using clearly defined assumptions.
IH SkinPerm does all of this using relatively few physical chemical inputs for the substance. The details of these calculations are all available from Dr. ten Berge (ref: specific documents (

Test material

Constituent 1
Chemical structure
Reference substance name:
Tributyl benzene-1,2,4-tricarboxylate
EC Number:
EC Name:
Tributyl benzene-1,2,4-tricarboxylate
Cas Number:
Molecular formula:
1,2,4-tributyl benzene-1,2,4-tricarboxylate

Results and discussion

Percutaneous absorption
5096 mg
ca. 0.2 %
Remarks on result:
other: 4 h

Any other information on results incl. tables



EC name: tributyl benzene-1,2,4-tricarboxylate

CAS number: 1726-23-4

Molecular weight: 378.46

Temperature: 25 °C

Vapour Pressure: 0.000598 Pa

Water solubility: 5.9 mg/L

Log Kow (skin, pH= 5.5): 6.17

Density: 1061.7 mg/cm3


Scenario parameters

Instantaneous deposition

- Deposition dose*: 5096 mg

- Affected skin area**: 1000 cm2

- Thickness of stagnant air***: 1 cm


Timing parameters

- Start deposition: 0 hr

- End time observation: 4 hr


Report parameters

- Calculationintervals/hours: 7200

- Report intervals/hours: 60


* Approximately 2 mL of a liquid having a viscosity similar to water will practically wet the palms of two hands (ca. 420 cm2). So 4.8 mL will wet all the skin surface of both hands. Ii is reasonably expected more liquid will be excess and wash/fall off.


** Estimated skin surface of two hands of an adult.


*** Nude skin.


Deposition: Instantaneous

Tot. Deposition: 5096 mg

End time observation: 4 hr


Fraction absorbed: 0.2%

Amount absorbed: 10.3 mg

Lag time stratum corneum: 29.6 min.


Max. derm. abs.: 1.29E-03 mg/cm2/hr

Max. derm. abs. for 2000 cm2in 1 hour (from liquid): 2.58 mg


Dermal/Respiratory uptake ratio (from airborne vapour): R= 3.062



RX: total dermal absorption by dermal exposure to airborne vapour

X:  total inhalation absorption from airborne vapour


Assuming that Fully Respiratory Protection provides 100% efficiency:


Protection from respirator= 100*X/(RX+X)= 100/(R+1)= 100/4.062= 24.6% protection against overexposure to the substance in the form of vapour due to dermal vapour absorption over whole body surface.

Applicant's summary and conclusion

The dermal absorption of tributyl benzene-1,2,4-tricarboxylate leads to the following results, obtained using the SkinPerm v1.21 model according to the input data:

Fraction absorbed: 0.5%
Amount absorbed: 10.3 mg
Lag time stratum corneum: 29.6 min.

Max. derm. abs.: 1.29E-03 mg/cm2/hr
Max. derm. abs. for 2000 cm2 in 1 hour (from liquid): 2.58 mg

Dermal/Respiratory uptake ratio (from airborne vapour): R= 3.062
Executive summary:

In-silico evaluation of dermal absorption indicates that after 4 hours only a very small amount of deposited substance is absorbed within viable epidermis and therefore enter in systemic circulation.