6-chlorohexan-2-one

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: data from publication

Data source

Reference

Reference Type:

publication

Title:

Cycloalkanones. 7. Hypocholesterolemic Activity of Aliphatic Compounds Related to 2,8-Dibenzylcyclooctanone

Author:

G. L. Carlson,I. H. Hall, and C. Piantadosi

Year:

1975

Bibliographic source:

Journal of Medicinal Chemistry, 1975, Vol. 18, No. 10 pp 1024-1026

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: as per mentioned below

Principles of method if other than guideline:

The developmental toxicity test has been conducted on chemical 2-octanone,exposed to male CF1 mice intraperitonialy daily with dose concentration of 50mg/kg/day.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Octan-2-one

EC Number:

203-837-1

EC Name:

Octan-2-one

Cas Number:

111-13-7

IUPAC Name:

octan-2-one

Details on test material:

- Name of test material: Octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.21 g/mol
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:

mouse

Strain:

CF-1

Details on test animals or test system and environmental conditions:

Details on test animal & Environmental conditions

TEST ANIMALS
- Source: Carworth Farms
- Age at study initiation: No data available
- Weight at study initiation: No data available
- Fasting period before study: No data available
- Housing: No data available
- Diet (e.g. ad libitum): Purina lab chow
- Water (e.g. ad libitum): ad libitum - Acclimation period: No data available

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available

IN-LIFE DATES: From: To:

Administration / exposure

Route of administration:

other: Intraperitonial

Type of inhalation exposure (if applicable):

not specified

Vehicle:

other: carboxymethylcellulose- H20(CMC)

Details on exposure:

Details on exposure

PREPARATION OF DOSING SOLUTIONS:
Test compound was suspended in 1% carboxymethylcellulose- H20 (1% CMC) and homogenized. Doses (mg/kg) were calculated on daily weights of the mice


VEHICLE
- Justification for use and choice of vehicle (if other than water):No data available
- Concentration in vehicle:50 mg/kg/day
- Amount of vehicle (if gavage):1%

Analytical verification of doses or concentrations:

not specified

Details on analytical verification of doses or concentrations:

No data available

Details on mating procedure:

No data available

Duration of treatment / exposure:

No data available

Frequency of treatment:

Daily

Duration of test:

19.4 days- average gestation time

No. of animals per sex per dose:

No data available

Control animals:

yes

Details on study design:

Control animals were given 1% CMC only

Examinations

Maternal examinations:

Antifertility activity

Ovaries and uterine content:

No data available

Fetal examinations:

Yes,Average number of fetuses per litter

Statistics:

the number of animals in a group, expressed as N, the mean of the percent of control, and standard deviation, expressed as i f S.D.,ar e noted. The probable
significant level ( p ) was determined by the Student's t test according to the procedure of Snedecor.

Indices:

No data available

Historical control data:

No data available

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:

Maternal toxic effects:no effects. Remark: no antifertility was observed at an effective dose level.

Effect levels (maternal animals)

Key result

Dose descriptor:

NOAEL

Effect level:

50 mg/kg bw/day

Based on:

test mat.

Basis for effect level:

other: developmental toxicity

Results (fetuses)

Details on embryotoxic / teratogenic effects:

Embryotoxic / teratogenic effects:yes. Remark: Average no. of fetuses per litter – no significant change was observed as compared to control.

Effect levels (fetuses)

Key result

Remarks on result:

not measured/tested

Fetal abnormalities

Key result

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Applicant's summary and conclusion

Conclusions:

The no observed adverse effect level was found to be 50 mg/kg/day when exposed to female mice intraperitonially by chemical 2-octanone daily for 19.4(gestation days) days.

Executive summary:

The developmental toxicity test has been conducted on chemical 2-octanone,exposed to male CF1 mice intraperitonialy daily with dose concentration of 50mg/kg/day.the number of viable fetuses per litter was observed in the test.No significant change was observed as compared to control.Hence, The no observed adverse effect level was found to be 50 mg/kg/day when exposed to female mice intraperitonially by chemical 2-octanone daily for 19.4(gestation days) days..