Registration Dossier
Registration Dossier
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EC number: 203-266-8 | CAS number: 105-06-6
Endpoint summary
Administrative data
Description of key information
Hydrolysis
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,4-Bis(ethenyl)benzene can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 37-50, 39-59 and 49-52 days at pH 4, 7 and 9 at 25°C, respectively.Thus, based on this half-life value, it can be concluded that the test chemical 1,4-Bis(ethenyl)benzene is not hydrolysable.
Additional information
Hydrolysis
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the half-life of the test chemical 1,4-Bis(ethenyl)benzene. The studies are as mentioned below:
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of 50°C and pH of 4, 7 and 9, respectively. No hydrolysis was noted at any of the three levels of pH tested and thus was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 50⁰C for 5 days. The half-life value of test chemical was determined to be > 5 days at pH 4, 7 and 9, respectively & at a temperature of 50⁰C. Thus based on this, test chemical is considered to be not hydrolysable.
The half-life of the test chemical was determined at different pH range. The study was performed according to OECD Guideline 111 (Hydrolysis as a Function of pH). A preliminary test was conducted with fortified samples in pH 4, 7 and 9 buffer solutions over a five–day period at 50 +/- 1°C.The definitive test was conducted with fortified samples in pH 4, 7 and 9 buffer solutions maintained at 15 and 25°C.Samples were subjected to seven sampling intervals over a 30-day period. Samples incubated at 15°C were collected on Day 0. Thereafter samples were collected on Days 2, 3, 10, 25 and 30. Samples incubated at 25°C were collected at Days 0, 2, 3, 10, 17 and 30. Duplicate samples were analyzed at each interval for the 25 degree test, while single samples were analyzed from the 15 degrees C test. Each of the constituents of test chemical were analyzed to determine the test substance concentration in the samples.The half-life value of test chemical at temperature of 15°C was not known, but was reported to be hydrolytically stable at pH 4, 7 and 9, respectively at a temperature of 15 whereas at temperature of 25°C, the half-life value of test chemical was determined to be ranges from 37-50, 39-59 and 49-52 days at pH 4, 7 and 9, respectively. Thus based on this, test chemical is considered to be not hydrolysable.
On the basis of the experimental studies of the structurally and functionally similar read across chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical 1,4-Bis(ethenyl)benzene can be expected to be > 5 days at pH 4, 7 and 9 & at a temperature of 50⁰C or 37-50, 39-59 and 49-52 days at pH 4, 7 and 9 at 25°C, respectively. Thus, based on this half-life value, it can be concluded that the test chemical 1,4-Bis(ethenyl)benzene is not hydrolysable.
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