Registration Dossier

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Referenceopen allclose all

Reference Type:
secondary source
Title:
Bericht ueber die gewerbetoxikologische Grundpr├╝fung
Author:
BASF AG
Year:
1979
Bibliographic source:
BASF AG, Abteilung Gewerbehygiene und Toxikologie: (1979)
Reference Type:
other: Authoritative data base
Title:
GCID: 512735
Author:
ACToR database
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource):- BASF AG, Abteilung Gewerbehygiene und Toxikologie: Bericht ueber die gewerbetoxikologische Grundpr├╝fung (1979)

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
The test substance was applied at a dose of 50 mg/animal and the animals were observed for a period of 8 days.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material: N,N-diethylaniline
- Substance type: Organic
- Physical state: Liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
50 mg
Duration of treatment / exposure:
no data
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
no data

Results and discussion

Results of in vivo study
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 8 days
Reversibility:
not specified
Remarks on result:
other: Dose: 50 mg/animal ; result: not irritating
Other effects:
Not irritating at a dose concentration of 50 mg/animal

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
In the acute eye irritation study in rabbits N,N-diethylaniline showed no eye irritation at a concentration of 50mg/animal suggesting that N,N-diethylaniline was not irritating to eyes.
Executive summary:

In the acute eye irritation study in rabbits N,N-diethylaniline showed no eye irritation at a concentration of 0.1 ml/animal suggesting that N,N-diethylaniline was not irritating to eyes.