Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from peer-reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicologic Properties of Fluorescent Whitening Agents
Author:
Ch. Gloxhuber and H. Blochmg
Year:
1978
Bibliographic source:
Clinical Toxicology 13 (2), pp. 171-203 (1978)
Reference Type:
other: Authorised database
Title:
Acute oral toxicity study for the test chemical 91-44-1
Author:
Canadian Centre for Occupational health and Safety
Year:
2016
Bibliographic source:
RTECS Number GN6370000, 2016

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of 7-Diethylamino-4-methylcoumarin in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
7-(diethylamino)-4-methyl-2-benzopyrone
EC Number:
202-068-9
EC Name:
7-(diethylamino)-4-methyl-2-benzopyrone
Cas Number:
91-44-1
Molecular formula:
C14H17NO2
IUPAC Name:
7-(diethylamino)-4-methyl-2H-chromen-2-one
Constituent 2
Reference substance name:
7-Diethylamino-4-methylcoumarin
IUPAC Name:
7-Diethylamino-4-methylcoumarin
Details on test material:
- Name of test material (as cited in study report): 7-Diethylamino-4-methylcoumarin
- Molecular formula (if other than submission substance): C14H17NO2
- Molecular weight (if other than submission substance): 231.2933 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: Mortality observed
Mortality:
No data available
Clinical signs:
other: No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 was considered to be 5000 mg/kg bw when rat were treated with 7-Diethylamino-4-methylcoumarin orally.
Executive summary:

In a acute oral toxicity study, rat were treated with 7-Diethylamino-4-methylcoumarin orally in the concentrations of 5000 mg/kg bw. 50 % mortality was observed in treated rats. Therefore, LD50 was considered to be 5000 mg/kg bw when rat were treated with 7-Diethylamino-4-methylcoumarin orally.