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Toxicity to aquatic algae and cyanobacteria

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Description of key information

72 hrs aquatic toxicity study was predicted (SSS QSAR Prediction model, 2016) to assess toxic effects of the test compound 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone (CAS No. 27425-55-4) and the results were predicted. The study was based on the effects of the test compound on Pseudokirchnerella subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone (CAS No. 27425-55-4) was estimated to be 15.956 mg/l on the basis of growth rate. Thus based on this value, it can be concluded that the substance can be classified as aquatic chronic category 3. Since the test chemical is readily biodegradable in nature, test chemical 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone can be considered as non-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.

Key value for chemical safety assessment

EC50/LC50 for freshwater algae:
15.95 mg/L

Additional information

72 hrs aquatic toxicity study was predicted (SSS QSAR Prediction model, 2016) to assess toxic effects of the test compound 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone (CAS No. 27425-55-4) and the results were predicted. The study was based on the effects of the test compound on Pseudokirchnerella subcapitata in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone (CAS No. 27425-55-4) was estimated to be 15.956 mg/l on the basis of growth rate. Thus based on this value, it can be concluded that the substance can be classified as aquatic chronic category 3. Since the test chemical is readily biodegradable in nature, test chemical 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone can be considered asnon-toxic to aquatic organisms and thus cannot be classified as hazardous as per the CLP criteria.