Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The median Effective concentration (EC50) value for 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone on Daphnia magna in a 48 hour study was estimated to be 32.30059433 mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
32.3 mg/L

Additional information

Various predicted data for the target chemical 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone were reviewed to summarize the following information: 

48 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was conducted to assess toxic effects of the test compound 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone (CAS no:27425 -55 -4) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound was estimated to be 32.30059433 mg/l.

According to the result, chemical was classified in chronic catagory 3 but as the it was readily biodegradable the chemical was considered as not classified as per CLP regulation.

Short term toxicity to aquatic invertebrates was estimated for 48 hrs aquatic toxicity study (EPI suite, 2016 ECOSAR version 1.1)

was conducted to assess toxic effects of the test compound 3-(1H-benzimidazol-2-yl)-7-(diethylamino)-2-benzopyrone (CAS no 27425 -55 -4) and the results were predicted. The study was based on the effects of the test compound on Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) for the test compound was estimated to be 5.648 mg/l.  According to CLP regulations, the chemical was classified in chronic category 2 but as the chemical was readily biodegradable, hence the chemical was considered as not classified.

On the basis of results of various predictions for toxicity to aquatic invertebrates, it can be considered that the substance is not likely to be toxic to aquatic invertebrates at environmentally relevant concentrations and also can be classified as non- hazardous as per the criteria of CLP regulation.