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Description of key information

In vitro bioavailability studies in simulated body fluids were conducted with the target substance tantalum carbide. Only in the artificial interstitial body fluid the release of tantalum was above the detection limit of the method, namely 0.005%.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

The bioaccessibility of tantalum carbide as a surrogate for bioavailability was measured. For this purpose soluble tantalum ions were measured using the EPA method #200.8 (ICP/MS) after incubation of tantalum carbide in different simulated body fluids (simulated gastric fluid, simulated interstitial fluid, simulated lysosomal fluid and artificial perspiration).

In summary, in all body fluids the release of tantalum ions was below the detection limit of the methodology used, except for the simulated lysosomal body fluid, in which the release of tantalum was measured with 0.005%. Based on the results, the bioavailability of tantalum carbide can be considered to be very low for all routes of administration.