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EC number: 231-755-6 | CAS number: 7721-01-9
In this in vitro assessment of the mutagenic potential of the test substance in accordance to OECD guideline 471, histidine dependent auxotrophic mutants of Salmonella typhimurium, strains TA1535, TA1537, TA98 and TA100, and a tryptophan dependent mutant of Escherichia coli, strain WP2uvrA/pKM101 (CM891), were exposed to the test substance diluted in purified water containing 0.15% agar. Purified water containing 0.15% agar was also used as a negative control.
Two independent mutation tests were performed in the presence and absence of liver preparations from Aroclor 1254-induced rats (S9 mix). The first (range-finding) test was a standard plate incorporation assay; the second involved a pre-incubation stage.
The concurrent positive controls demonstrated the sensitivity of the assay and the metabolising activity of the liver preparations.
It is concluded that, under the test conditions, the test substance showed no evidence of mutagenic activity in this bacterial system. Ta2O5 Tantalum Pentoxide Grade LT is used as read-across partner to tantalum pentachloride.
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