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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication, which meets generally accepted scientific standards.

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum and yttrium.
Author:
Cochran KW, Doull J, Mazur M, Dubois KP.
Year:
1950
Bibliographic source:
Arch Ind Hyg Occup Med.;1(6):637-50.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Study is an acute oral toxicity, but as the study is from 1950 no OECD guideline for acute oral toxicity was available at that time
GLP compliance:
no
Test type:
other: acute oral toxicity
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tantalum pentachloride
EC Number:
231-755-6
EC Name:
Tantalum pentachloride
Cas Number:
7721-01-9
Molecular formula:
Cl5Ta
IUPAC Name:
tantalum pentachloride
Details on test material:
- Name of test material (as cited in study report): Tantalum chloride

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): purina chow, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
The animals were maintained in air-conditioned rooms

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
A 50% aqueous solution of the salt was injected as the solubility permitted.
Doses:
No information was provided
No. of animals per sex per dose:
In total 22 rats were treated
Control animals:
not specified
Details on study design:
The solution was given in single doses orally by stomach tube. All animals were observed for ten days. It was found that a ten day observation period was sufficient, since animals either succumbed or recovered during this period.
Statistics:
The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 900 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 value in rats after treatment with tantalum pentachloride was determined in a pre-OECD study to be 1900 mg/kg body weight.
Executive summary:

In an acute oral toxicity study male and female Sprague-Dawley rats (in total 22 rats) were orally treated with tantalum pentachloride in water. Animals were observed for 10 days. Based on the mortality, an oral LD50 of 1900 mg/kg bw was determined for both sexes.