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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Publication, which meets generally accepted scientific standards.

Data source

Reference
Reference Type:
publication
Title:
Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum and yttrium.
Author:
Cochran KW, Doull J, Mazur M, Dubois KP.
Year:
1950
Bibliographic source:
Arch Ind Hyg Occup Med.;1(6):637-50.

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Study is an acute oral toxicity, but as the study is from 1950 no OECD guideline for acute oral toxicity was available at that time
GLP compliance:
no
Test type:
other: acute oral toxicity
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Tantalum chloride

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): purina chow, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
The animals were maintained in air-conditioned rooms

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Details on oral exposure:
A 50% aqueous solution of the salt was injected as the solubility permitted.
Doses:
No information was provided
No. of animals per sex per dose:
In total 22 rats were treated
Control animals:
not specified
Details on study design:
The solution was given in single doses orally by stomach tube. All animals were observed for ten days. It was found that a ten day observation period was sufficient, since animals either succumbed or recovered during this period.
Statistics:
The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 900 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The oral LD50 value in rats after treatment with tantalum pentachloride was determined in a pre-OECD study to be 1900 mg/kg body weight.
Executive summary:

In an acute oral toxicity study male and female Sprague-Dawley rats (in total 22 rats) were orally treated with tantalum pentachloride in water. Animals were observed for 10 days. Based on the mortality, an oral LD50 of 1900 mg/kg bw was determined for both sexes.