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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2010-05-28
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Justification for type of information:
See section 13.2 for the read-across justification.
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
OECD Guideline 123 (Partition Coefficient (1-Octanol / Water), Slow-Stirring Method)
Deviations:
yes
Remarks:
Some adjustments have been done. The concentration of the surfactant are below the CMC value, pH has been adjusted to 5-6
GLP compliance:
no
Type of method:
other: slow stir
Partition coefficient type:
octanol-water
Type:
log Pow
Partition coefficient:
3.6
Temp.:
25 °C
pH:
5 - 6

The measurements were made at a pH of 5-6 and at an initial concentration of 1.83 mg/L in the water phase (about 50% of the critical micelle

concentration (CMC) in water) and at 25°C. The partition coefficient value was determined from the weighed average of the concentrations of the main components in the product listed in the table below.

 

Substance

Log POW

Bis (2 -hydroxyethyl) hydrogenated tallow alkylamine

3.6

with the following results of its components:

Bis (2-hydroxyethyl) dodecyl amine

 

1.9

 

Bis (2-hydroxyethyl) tetradecyl amine

 

3.2

  

Bis (2-hydroxyethyl) hexadecyl amine

  

4.4

  

Bis (2-hydroxyethyl) octadecyl amine

  

3.8

Conclusions:
The partition coefficient of the registered substance is 3.6 (log Pow).
Executive summary:

The partition coefficient was determined to be 3.6 (log Pow) for 2,2'-(C16-18 (even numbered) alkyl imino) diethanol (PFAEO C16-18). Since the source substance is a substance with the same structure and a comparable alkyl chain length, these data are used as a worst case value for Octadecylbi(2-hydroxyethyl)amine (PFAEO C18).

Description of key information

The partition coefficient was determined to be 3.6 (log Pow) for 2,2'-(C16-18 (even numbered) alkyl imino) diethanol (PFAEO C16-18). Since the source substance is a substance with the same structure and a comparable alkyl chain length, these data are used as a worst case value for Octadecylbi(2-hydroxyethyl)amine (PFAEO C18).

Key value for chemical safety assessment

Log Kow (Log Pow):
3.8
at the temperature of:
25 °C

Additional information