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Toxicity to aquatic algae and cyanobacteria

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Description of key information

No toxic effects to aquatic algae up to the limit of water solubility (OECD 201), read across

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Since no experimental studies investigating the toxicity of 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3) to algae are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally related source substance Dipentaerythritol ester with fatty acids, C5 and C9iso (CAS 647028-25-9) was conducted. This read-across is justified in detail in the overall summary (IUCLID section 6.1) and within the analogue justification in IUCLID Section 13. Both substances consists of the same alcohol component (dipentaerythritol) and a similar fatty acid chain lengths as the target substance (C9iso for the target substance compared to C5 and 9iso for the source substance).

The study with the read-across substance Dipentaerythritol ester with fatty acids, C5 and C9iso (CAS 647028-25-9) investigated the toxicity to algae in a GLP guideline study. The test was performed according to OECD 201 (Mead and Mullee, 2000) with Scenedesmus subspicatus exposed to a water accommodated fraction with a limit concentration of 100 mg/L. The test substance concentration was analysed using GC-analysis and resulted in a concentration of < 0.18 mg/L (limit of quantification). No inhibition was observed after 72 h. Therefore, this study resulted in an EL50 of > 100 mg/L (nominal). The NOELR was derived to be >= 100 mg/L (nominal).

Based on the available results from this structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which is characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that of 3,5,5 trimethylhexanoic acid, mixed esters with dipentaerythritol (CAS 84418-63-3) will not exhibit adverse effects on algae up to the limit of water solubility.