Registration Dossier
Registration Dossier
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EC number: 202-255-5 | CAS number: 93-53-8
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Monographs on fragrance raw materials: Hydratropic aldehyde
- Author:
- D.L.J Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology ; Volume 13, Issue 5, October 1975, Pages 548
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity study was carried out in rabbits.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Hydratropaldehyde
- EC Number:
- 202-255-5
- EC Name:
- Hydratropaldehyde
- Cas Number:
- 93-53-8
- Molecular formula:
- C9H10O
- IUPAC Name:
- hydratropaldehyde
- Reference substance name:
- 2 Phenylpropanal
- IUPAC Name:
- 2 Phenylpropanal
- Details on test material:
- - Name of test material (as cited in study report): Hydratrophic Aldehyde (2 Phenylpropanal)
- Substance type: Organic
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- no data
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute dermal study in rats, the acute dermal LD50 for Hydratrophic aldehyde (2 Phenyl propanal) was found to be greater than 5000 mg/kg
- Executive summary:
Acute Dermal study was carried out in rabbits.
The test chemical was applied onto the skin of rabbits.
The acute dermal LD50 for Hydratrophic aldehyde (2 Phenyl propanal) was found to be greater than 5000mg/kg.
Based on value the chemical was not classified as per CLP regulations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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