Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

The available data does not mention in details about the absorption, distribution, metabolism and excretion of the chemical Hydratropic aldehyde, when fed by stomach tube to Chinchilla rabbits. The study indicates that upon administration of Hydratropic aldehyde, the metabolites Hydratropoylglucuronide, Hydratropoylglucosiduronic acid & Hydratropyl alcohol are formed which are excreted out of the body of rabbit via urine. However, in the absence of the information of the % recovery of the administered test chemical, it is not possible to conclude on the bio-accumulation potential of Hydratropic aldehyde.
However, the summary of evaluations performed by the Joint FAO/WHO Expert Committee on Food Additives (Jan 2006) for 2-PHENYLPROPIONALDEHYDE (Synonym for Hydratropic aldehyde) when used as a food additive, indicate no safety concern at current levels of intake when Hydratropic aldehyde is used as a flavouring agent. Thus considering the above, it can be concluded that since Hydratropic aldehyde is metabolized in the study with rabbits, the chemical is expected to exhibit Low bioaccumulation potential.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential

Additional information

Upon administration of Hydratropic aldehyde, as suspension in water, to Chinchilla rabbits by oral gavage, the metabolites Hydratropoylglucuronide, Hydratropoylglucosiduronic acid & Hydratropyl alcohol are formed which are excreted out of the body of rabbit via urine. However, in the absence of the information of the % recovery of the administered test chemical, it is not possible to conclude on the bio-accumulation potential ofHydratropic aldehyde.

However, the summary of evaluations performed by the Joint FAO/WHO Expert Committee on Food Additives (Jan 2006) for 2-PHENYLPROPIONALDEHYDE (Synonym forHydratropic aldehyde) when used as a food additive, indicate no safety concern at current levels of intake when Hydratropic aldehyde is used as a flavouring agent.

Thus considering the above, it can be concluded that since Hydratropic aldehyde is metabolized in the study with rabbits, the chemical is expected to exhibit Low bioaccumulation potential.