2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16-09-2016 – 22-09-2016

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

0.051 mg/L

Conc. based on:

test mat.

Temp.:

28 °C

Remarks on result:

other: othr detals not spcecified

Table 1:

Sr. No.	Aliquot of stock solution taken (ml)	Amount of water added to make up the volume (ml)	Concentration of Standard Solution (mg/l)
1.	4	16	4
2.	8	12	8
3.	12	8	12
4.	16	4	16
5.	20	0	20

The absorbances of these standard solutions were taken at446 nm (λ max) and the standard curve was plotted between absorbance versus concentrations (mg/l). The spectrophotometer used for the analysis was UV-6300PC; make VWR.

Conclusions:

The water solubilitydetermination of test item 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione;CAS No.19125-99-6 was done by spectrophotometric method. The water solubility was found to be 0.0507 mg/L at 28°C.

Executive summary:

The water solubility determination of test item 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No. 19125 -99-6) was done as per the OECD guideline 105 byspectrophotometric analytical method as per OECD 101. The solubility of (2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione of 19125-99-6 )in water was found to be 0.0507 mg/L at 28°C. This indicates the test substance to be insoluble in water.

Description of key information

The water solubilitydetermination of test item 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione;CAS No.19125-99-6 was done by spectrophotometric method. The water solubility was found to be 0.0507 mg/L at 28-°C.

Key value for chemical safety assessment

Water solubility:

0.051 mg/L

at the temperature of:

28 °C

Additional information

The water solubility determination of test item 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No. 19125 -99-6) was done as per the OECD guideline 105 byspectrophotometric analytical method as per OECD 101. The solubility of (2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione of 19125-99-6 )in water was found to be 0.0507 mg/L at 28 °C.

Other supporting data from EPI suite modeling database estimates the solubility as 0.14 mg/L, which also indicates the marginal solubility or negligibly solubility in water.

Thus the test substance 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione is concluded to be insoluble in water considering 0.0507 mg/L as the key value for safety assessment.