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EC number: 242-828-7 | CAS number: 19125-99-6
Endpoint summary
Administrative data
Description of key information
Appearance:
On the basis of physical
observation, the test chemical
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (Common
Name: Solvent Yellow 43) was found to be a yellow colored powder.
Melting Point:
The melting point determination of 2-butyl-6-(butyl
amino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No. 19125-99-6) was
done following OECD Guideline 102 and according to the metal block
capillary method. The test was conducted in replicates and mean melting
point was found to be 110.8°C -118 °C at 972.4 hPa.
Boiling Point:
The boiling point determination
of 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No.
19125-99-6) was done following OECD Guideline 103 and according to the
method of Siwoloboff. The boiling point was found to be greater than
250°C at 968.9 hPa.
Density:
The mean density of test
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No.
19125-99-6) was determined following OECD Guideline 109 and according to
the method adapted from ASTM D 854-02 using glass pyknometer .The mean
density of the test item was found to be 0.4006 g/cm3 at 20° C and
970.8 hPa.
Particle size distribution:
The particle size distribution of
test item 2-butyl-6-(butylamino)-1H-benz
[de]isoquinoline-1,3(2H)-dione(CAS No. 19125-99-6) was determined by
granulometric analysis with rotap sieve shaker. The particle size
distribution was found to be in the range of 150 micron to 25 micron.
This indicates that the particles are not of inhalable size.
Vapour pressure:
The vapour pressure of the test
compound2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dioneas
predicted by EPI suite (Modified Grain method) is estimated to be
0.00000000141 Pa.
Partition coefficient:
The partition coefficient of test
substance 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione
(CAS No.19125-99-6)was determined as per the HPLC method (OECD
Guideline-117). The Log Pow value was found to be 4.643 ± 0.002 at 25°C.
Water solubility:
The water solubilitydetermination
of test item
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione; CAS
No.19125-99-6 was done by spectrophotometric method. The water
solubility was found to be 0.0507 mg/L at 28°C.
Surface tension:
In accordance with column 2 of
Annex VII of the REACH regulation, this testing needs to be carried out
only if surface activity is a desired property of the chemical. The
chemical 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione
(Common name: Solvent Yellow 43) is used as a Fluorescent color. For
this use, surface activity is not a desired property and hence this end
point was considered for waiver.
Flash point:
The flash point determination of
Test item 2-butyl-6-(butyl amino)-1H-benz[de]isoquinoline-1,3(2H)-dione
(CAS No. 19125-99-6) was done. The method is closed cup method using
Pensky-Martens Flash Point Apparatus. The flashpoint of the test item
was found to be 248.3°C at 974.1 hPa.
Auto Flammability:
2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione
did not catch fire on being exposed to air at room temperature of 27°C
pressure of 966 hPa. This indicates that
2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione is not
auto-flammable.
Flammability:
The NFPA rating for the chemical
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (Common
name: Solvent Yellow 43) for flammability is ranges between 0 to 1,
indicating that the chemical is not likely to be flammable under normal
conditions of temperature and pressure. Thus, this end point was
considered for waiver. The chemical is considered as "Non Flammable" for
the purpose of chemical safety assessment.
Explosiveness:
In accordance with column 2 of
Annex VII of the REACH regulation, the study is scientifically
unjustified since there are no chemical groups associated with explosive
properties present in the molecule of the chemical
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (Common
name: Solvent Yellow 43). Thus, the chemical is not likely to be
explosive and has been considered to be "Non-explosive" for the purpose
of chemical safety assessment.
Oxidising properties:
The study does not need to be
conducted because there are no chemical groups present in the molecule
which are associated with oxidising properties and hence, the
classification procedure does not need to be applied.
pH:
The pH determination of test item
2-butyl-6-(butyl amino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No.
19125-99-6 )was done following OECD guideline 122. pH of 1% w/v aqueous
dispersion was measured with the help of pH meter and it was observed
to be 6.83 at 29.6°C.
Additional information
Appearance:
On the basis of physical
observation, the test chemical
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (Common
Name: Solvent Yellow 43) was found to be a yellow colored powder.
Melting Point:
The melting point determination of Test item 2-butyl-6-(butyl
amino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No. 19125-99-6) was
done as per the test guideline OECD 102. The method followed was
according to capillary/metal block. The melting range was found to be
110.8°C -118 °C at 972.4hPa. There was no decomposition observed.
Other supporting data from authoritative database and handbook indicates the melting point to be in the range of 123 - 349.84°C.
As the data from lab has K1 reliability and the test was performed using OECD guidelines which has the value of melting point as 110.8°C -118 °C, thus considered as key study for chemical safety assessment.
Boiling Point:
The boiling point determination
of 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No.
19125-99-6 ) was done following OECD Guideline 103 and according to the
method of Siwoloboff. The boiling point was found to be greater than
250°C at 968.9 hPa.
Other data from EPI Suite estimation database indicates the boiling point value as 545.67, which supports the key value of target i.e. >250°C.
Density:
The density of test item
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No.
19125-99-6) was determined following OECD guideline 109 and according to
the method adapted from ASTM D 854-02. The mean density of the test item
was found to be 0.4006 g/cm3at 20oC and 970.8 hPa .
Particle size distribution:
The particle size distribution of
test item 2-butyl-6-(butylamino)-1H-benz
[de]isoquinoline-1,3(2H)-dione(CAS No. 19125-99-6) was determined by
granulometric analysis with rotap sieve shaker. The particle size
distribution was found to be in the range of 150 micron to 25 micron.
This indicates that the particles are not of inhalable size.
Vapour pressure:
The vapour pressure of the test
compound2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dioneas
predicted by EPI suite (Modified Grain method) is estimated to be
0.00000000141 Pa.
Partition coefficient:
Prediction model based estimation
and data from study report are used to determine the partition
coefficient for the test chemical CAS no 19125 -99 -6. The summary is as
below:
The partition Coefficient n-octanol/water of2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (CAS No. 19125-99-6)was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals (Sustainiability support services, 2016). The reference substances were chosen according to structural similarity with the test substance and calibration graph was prepared. The reference substances were Benzene, Toluene, Ethylbenzene, Naphthalene, Biphenyl, and n- butylbenzene having Pow value ranging from 2.1 to 4.6.The Log Pow value was found to be 4.643 ± 0.002 at 25°C.
The partition coefficient (Log Kow/Pow) of the test compound 4-Butylamino-N-butyl-1,8-naphthalimide as predicted by EPI suite is estimated to be 4.7807.
Both the values indicate the substance to be hydrophobic in nature which is in turn supported by its water solubility.
Water solubility:
The water solubilitydetermination
of test item
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione; CAS
No.19125-99-6 was done by spectrophotometric method. The water
solubility was found to be 0.0507 mg/L at 28°C.
Surface tension:
In accordance with column 2 of
Annex VII of the REACH regulation, this testing needs to be carried out
only if surface activity is a desired property of the chemical. The
chemical 2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione
(Common name: Solvent Yellow 43) is used as a Fluorescent color. For
this use, surface activity is not a desired property and hence this end
point was considered for waiver.
Flash point:
The flash point determination
of2-butyl-6-(butyl amino)-1H-benz[de]isoquinoline-1,3(2H)-dione(CAS No.
19125-99-6)was done following closed cup method using Pensky-Martens
flash point apparatus. The test was conducted in replicates and mean
flash point was found to be 248.3°C at 974.1hPa.
Auto Flammability:
2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione
did not catch fire on being exposed to air at room temperature of 27°C
pressure of 966 hPa. This indicates that
2-butyl-6-(butylamino)-1H-benzo[de]isoquinoline-1,3(2H)-dione is not
auto-flammable.
Flammability:
The NFPA rating for the chemical
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (Common
name: Solvent Yellow 43) for flammability is ranges between 0 to 1,
indicating that the chemical is not likely to be flammable under normal
conditions of temperature and pressure. Thus, this end point was
considered for waiver. The chemical is considered as "Non Flammable" for
the purpose of chemical safety assessment.
Explosiveness:
In accordance with column 2 of
Annex VII of the REACH regulation, the study is scientifically
unjustified since there are no chemical groups associated with explosive
properties present in the molecule of the chemical
2-butyl-6-(butylamino)-1H-benz[de]isoquinoline-1,3(2H)-dione (Common
name: Solvent Yellow 43). Thus, the chemical is not likely to be
explosive and has been considered to be "Non-explosive" for the purpose
of chemical safety assessment.
Oxidising properties:
The study does not need to be
conducted because there are no chemical groups present in the molecule
which are associated with oxidising properties and hence, the
classification procedure does not need to be applied.
pH:
The pH determination of test
item2-butyl-6-(butyl amino)-1H-benz[de]isoquinoline-1,3(2H)-dione(CAS
No. 19125-99-6 ) was done as per the test guideline OECD 122. The pH of
the test solution was determined with the help of digitalpH meter. The
pH was found to be 6.83 at 29.6°C indicting that the 1% soultion of this
chemical is near neutral in pH.
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