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Toxicity to aquatic algae and cyanobacteria

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Description of key information

72 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was predicted to assess toxic effects of the test compound 4 -Aminoazobenzene-3,4'- disulfonic acid (CAS No. 101 -50 -8) and the results were predicted. The study was based on the effects of the test compound on Desmodesmus subspicatus in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-Aminoazobenzene-3,4'-disulfonic acid (CAS No. 101 -50 -8) was estimated to be 128.468963623 mg/L on the basis of growth rate.

Key value for chemical safety assessment

EC50 for freshwater algae:
128.469 mg/L

Additional information

Various predicted data for the target chemical 4-Aminoazobenzene-3,4'-disulfonic acid (CAS no. 101-50-8) were reviewed to summarize the following information:

 

72 hrs aquatic toxicity study (SSS QSAR prediction model, 2016) was predicted to assess toxic effects of the test compound 4 -Aminoazobenzene-3,4'- disulfonic acid (CAS No. 101 -50 -8) and the results were predicted. The study was based on the effects of the test compound on Desmodesmus subspicatus in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-Aminoazobenzene-3,4'-disulfonic acid (CAS No. 101 -50 -8) was estimated to be 128.468963623 mg/L on the basis of growth rate.

 

96 hrs aquatic toxicity study (EPI suite, 2016) waspredictedto assess toxic effects of the test compound 4-Aminoazobenzene-3,4'-disulfonic acid (CAS no. 101-50-8) and the results were predicted. The study was based on the effects of the test compound on green algae in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-Aminoazobenzene-3,4'-disulfonic acid (CAS no. 101-50-8) was estimated to be 12858.936 mg/l on the basis of growth rate.

 

72 hrs aquatic toxicity study (Danish (Q)SAR Database, 2016) was predicted to assess toxic effects of the test compound 4 - Aminoazobenzene-3,4'- disulfonic acid (CAS no. 101-50-8) and the results were predicted. The study was based on the effects of the test compound on Pseudokirchneriella spp. in a static fresh water system. The predicted data suggests the effective concentration (EC50) for the test compound 4-Aminoazobenzene-3,4'-disulfonic acid (CAS no. 101-50-8) was estimated to be 2749.327mg/L on the basis of growth rate.

 

 

 

On the basis of the above resultsof predicted data for target chemical, it can be concluded that the substance can be considered as non-toxic to aquatic organisms and thus, cannot be classified as hazardous as per the criteria of CLP regulation.