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Administrative data

Link to relevant study record(s)

Description of key information

With high probability acutely harmful to fish.

Key value for chemical safety assessment

Additional information

Experimental data on the toxicity of 2-ethylhexyl cyanoacetate (CAS 13361 -34 -7) to fish are not available. Regarding the tonnage band (1 -1000 t/a, intermediate) a study on the short-term toxicity to fish is not required. However, in order to assess the acute toxicity to fish, QSAR models were used.

The results of the applied models are listed below:

- US EPA T.E.S.T. v4.1 (consensus method, acceptable predictive power): 96 -h LC50 = 12.7 mg/L

- VEGA v1.0.8 96 hour fathead minnow LC50 v1.0.6 (could be out of applicability domain): 96 -h LC50 = 1.08 mg/L

Based on the reliable calculated data from the estimation model US EPA T.E.S.T. v4.1 (96 -h LC50 = 12.7 mg/L), the substance is assessed to be with high probability acutely harmful to fish.

QSAR-disclaimer

 

In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.

 

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

 

For the assessment of HOPz 2-ethylhexyl cyanoacetate (CAS 13361 -34 -7), (Q)SAR results were used for toxicity to aquatic organisms.The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

 

Therefore, and for reasons of animal welfare further experimental studies on aquatic toxicity are not provided.