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EC number: 229-246-9 | CAS number: 6448-96-0
Table 1: RESULTS OF RABBITS WITH EYE RINSED
Days after application
Rabbit 1 (female)
Rabbit 2 (female)
Rabbit 3 (female)
Table 2: RESULTS OF RABBITS WITH EYE NOT RINSED
Rabbit 4 (male)
Rabbit 5 (male)
Rabbit 6 (male)
An ocular irritation study was conducted to determine the primary-irritation index, which serves as a measure of the acute irritation, provoked by the test chemical on the eye of the rabbits. The study was performed according to the procedure adopted was the technique described in the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the US Association of Food and Drug Officials (AFDO).
About (0.1g) of the test chemical were introduced into the conjunctival sac of the left eye of six rabbits (3/sex) of Russian breed with a spatula. After application, the eyelids were held open for a few seconds. The right eye served as a control. The treated eyes of three rabbits were each rinsed with 10 ml lukewarm water about 30 seconds after treatment. The reactions were appraised with a slit-lamp after 24 hours and after 2,3,4 and 7 days on the basis of the "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959) of the AFDO.
The primary irritation index of the test chemical was estimated to be 0 for the cornea, 0 for the iris and 0 for the conjunctivae. Hence, the test chemical was considered to be not irritating to the rabbits’ eye.
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