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EC number: 213-022-2 | CAS number: 915-67-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Skin sensitization:
Based on the weight of evidence used and as per the CLP classification, the test material 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthalenyl), sodium salt (915-67-3) does not classify as a skin sensitizer.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data from peer - reviewed journals
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Principles of method if other than guideline:
- to assess the skin sensitizing potential of the test chemical
- GLP compliance:
- not specified
- Type of study:
- not specified
- Justification for non-LLNA method:
- not specified
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- no data
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- no data
- Route:
- other: no data
- Vehicle:
- no data
- Concentration / amount:
- no data
- No. of animals per dose:
- no data
- Details on study design:
- no data
- Challenge controls:
- no data
- Positive control substance(s):
- not specified
- Reading:
- other: mean
- Group:
- test chemical
- Dose level:
- no data
- No. with + reactions:
- 0
- Clinical observations:
- no data
- Remarks on result:
- other: Reading: other: mean. Group: test group. Dose level: no data. No with. + reactions: 0.0. Clinical observations: no data.
- Interpretation of results:
- not sensitising
- Conclusions:
- In experiments with guinea-pigs, it was found that Amaranth had no sensitization activity
- Executive summary:
In experiments with guinea‐pigs, it was found that Amaranth had no sensitization activity
Reference
Not Specified
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Various peer reviewed articles and from QSAR prediction to determine the sensitizing potential of the test compound 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthalenyl), sodium salt (CXAS 915-67-3). the summary is as below:
From Joint FAO/WHO Expert Committee on Food Additives which met in Geneva, 14‐23 April 1975; experiment study done on guinea‐pigs, it was found that Amaranth had no sensitization activity.
The sensitization potential of Acid Red 27 [also known as Amaranth] was estimated by using a quantitative structure–activity relationship (QSAR) model. Prediction of sensitization potency
Structures identified were then imported into a molecular spreadsheet TSAR (Version 3.3, Accelrys Ltd., Cambridge, UK). Simplified Molecular Input Line Entry Specifications (SMILES, www.daylight.com), which are 1-dimensional representations of chemical structures, were generated. This list was filtered in order to remove any further duplicate structures, such as salt-containing ingredients (HCl and SO4)
Ranking the substances according to their sensitization potential
The TOPS-MODE QSAR model was used in order to estimate the likely sensitization potency in 1 of 3 bands: strong/moderate sensitizers, weak sensitizers and Extremely weak or non-sensitizers.
The predicted sensitization potency numbers represent an arbitrary relative ranking scheme, which makes it possible to compare substances within the same group.
The predicted sensitizing potential of Acid Red 27 [also known as Amaranth] was estimated to be in the strong/moderate sensitizer group.
Skin sensitizing property of 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthalenyl), sodium salt (915-67-3) is predicted using QSAR toolbox version 3.3.
The substance 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthalenyl), sodium salt (915-67-3) is estimated to be not sensitizing in an in vivo test on human.
Based on the studies reviewed, it can be concluded that the test material 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthalenyl), sodium salt (915-67-3) is not a skin sensitizer.
Migrated from Short description of key information:
In experiments with guinea‐pigs, it was found that Amaranth had no sensitization activity
Justification for selection of skin sensitisation endpoint:
The test material Amaranth does not classify as a skin sensitizer.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Skin sensitization:
Based on the weight of evidence used and as per the CLP classification, the test material 2,7-Naphthalenedisulfonic acid, 3-hydroxy-4-[(4-sulfo-1-naphthalenyl), sodium salt (915-67-3) does not classify as a skin sensitizer.
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