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EC number: 943-328-8
CAS number: -
7.3.2/1: Eye irritation response data for each animal at each
Score at time point
0 / 0 / 0 / 0 / 0 / 0
1 / 1 / 1 / 1 / 0 / 1
1 / 1 / 1 / 0 / 0 / 0
1 / 2 / 1 / 0 / 0 / 0
Average 24h, 48h, and 72h
0.33 / 0.33 / 0.33 / 0.33 / 0 / 0.33
0.33 / 0.33 / 0.33 / 0 / 0 / 0
0.33 / 0.67 / 0.33 / 0 / 0 / 0
Average time (unit) for reversion
In an eye irritation study, 0.1 mL of
undiluted test material was instilled into the right eye of 6 albino
rabbits while the left eye remained untreated and served as control. The
eyes were not rinsed after the instillation of test material. Animals
were observed at 24, 48 and 72 after instillation of test material into
eyes and then on Days 5 and 7. The reactions in the conjunctivae
(redness, chemosis and discharge), the iris and the cornea (opacity and
area involved) were scored according to the Draize scale of scoring
The calculated mean score for each animal
within 3 scoring times (24, 48 and 72 h) were 0.33 / 0.33 / 0.33 / 0.33
/ 0 / 0.33 for redness, 0.33 / 0.33 / 0.33 / 0.33 / 0 / 0.33 for
chemosis, 0.33 / 0.33 / 0.33 / 0.33 / 0 / 0.33 for iris lesions and
corneal opacity. The observed conjunctival reactions were disappeared
completely within 2 days.
Under the test conditions, the test material
is not classified as irritating to the eyes according to the annex VI of
the Regulation EC No. 1272/2008 (CLP).
Although some details on test animals and
experimental conditions were missing, this study is considered as
acceptable and satisfies the requirement for eye irritation endpoint.
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