Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report Date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.8 (Partition Coefficient)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name of test material (as cited in study report): 2-Methoxy-5-Nitrophenyl Acetate
- Physical state: solid
- Analytical purity: more than 95 %

- Lot/batch No.: 102014
- Expiration date of the lot/batch: unlisted

- Stability under test conditions: unlisted
- Storage condition of test material: The test substance was stored in closed container in dark and dry at the room temperature.

Results and discussion

Partition coefficient
Type:
log Pow
Partition coefficient:
1.487
Temp.:
25 °C
pH:
6.72

Applicant's summary and conclusion

Conclusions:
Partition coefficient (log P) of the test substance (2-Methoxy 5-Nitrophenyl Acetate) is: log P = 1.49 +- 0.43 (25 °C, pH = 6.72)
Executive summary:

The partition coefficient of the test substance (2-Methoxy-Nitrophenyl Acetate) was determined. Based on the results of the preliminary estimation of the partition coefficient by a calculation method, the HPLC method was used for the main experiment.

The procedure was performed according to Method A.8. – Partition Coefficient, Council Regulation (EC) No.440/2008, Published in O.J. L 142, 2008.

Partition coefficient (log P) of the test substance (2-Methoxy 5-Nitrophenyl Acetate) is:

log P = 1.49 +- 0.43 (25 °C, pH = 6.72)