Registration Dossier
Registration Dossier
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EC number: 204-593-9 | CAS number: 123-03-5
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Rapidly eliminated in feces and urine
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
Using radiolabeled test material, the absorption, distribution and elimination of CPC after oral and intravenous administration was investigated in rats and Beagle dogs. The substance is primarily eliminated in the feces, up to 85% after oral administration and up to 37% after intravenous dosing. After oral dosing, the secondary route of elimination is the urine, approximately 5% after oral administration, and up to 32% route after intravenous dosing. No information is available concerning the metabolism of CPC (other than its conjugation with bile salts). A conservative value of 50% oral absorption may be applied, as per EFSA (2012). Considering the substance is a charged molecule, the dermal absorption is low, and a value of 10%, as per SCCS (2015), is applied.
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