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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Only one sex was used (females) and only seven rabbits were dosed
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4-isopropylbenzonitrile
EC Number:
237-492-3
EC Name:
4-isopropylbenzonitrile
Cas Number:
13816-33-6
Molecular formula:
C10H11N
IUPAC Name:
4-(propan-2-yl)benzonitrile
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): cumin nitrile #80-34
- Lot/batch No.: #80-34

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
female

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
24 hours
Doses:
5.0 g/kg
No. of animals per sex per dose:
7 females
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: other: GHS EU
Conclusions:
The LD50 was greater than 5.0 g/kg in female rabbits.