Registration Dossier
Registration Dossier
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EC number: 406-305-9 | CAS number: 92952-81-3 PLAKATROT Z; ROT BN
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Information from migrated NONS file as per inquiry # [06-0000024522-76-0000], permission to refer granted by ECHA
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.6 (Meerschweinchen-Maximierungstest (GPMT)); OECD 406
- GLP compliance:
- yes
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Available study not conducted specifically for REACH.
Test material
- Reference substance name:
- 4-[(3-hydroxypropyl)amino]-3-nitrophenol
- EC Number:
- 406-305-9
- EC Name:
- 4-[(3-hydroxypropyl)amino]-3-nitrophenol
- Cas Number:
- 92952-81-3
- Molecular formula:
- C9H12N2O4
- IUPAC Name:
- 4-[(3-hydroxypropyl)amino]-3-nitrophenol
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: dermal
- Vehicle:
- other: distilled water
- Concentration / amount:
- Intradermal induction : 10 w/v% in distilled water
Dermal induction : 50% w/v% in distilled water
Concentration of test material and vehicle used for each challenge : 25% w/v% in distilled water
Challengeopen allclose all
- Route:
- other: dermal
- Vehicle:
- other: distilled water
- Concentration / amount:
- Intradermal induction : 10 w/v% in distilled water
Dermal induction : 50% w/v% in distilled water
Concentration of test material and vehicle used for each challenge : 25% w/v% in distilled water
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- %
- No. with + reactions:
- 2
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: %. No with. + reactions: 2.0. Total no. in groups: 20.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- test chemical
- Dose level:
- %
- No. with + reactions:
- 3
- Total no. in group:
- 20
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: %. No with. + reactions: 3.0. Total no. in groups: 20.0.
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: %. No with. + reactions: 0.0. Total no. in groups: 10.0.
- Reading:
- 2nd reading
- Hours after challenge:
- 48
- Group:
- negative control
- Dose level:
- %
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: %. No with. + reactions: 0.0. Total no. in groups: 10.0.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
- Conclusions:
- Substance not classified as a skin sensitiser.
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