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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Information from migrated NONS file as per inquiry # [06-0000024522-76-0000], permission to refer granted by ECHA
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.6 (Meerschweinchen-Maximierungstest (GPMT)); OECD 406
GLP compliance:
yes
Type of study:
guinea pig maximisation test
Justification for non-LLNA method:
Available study not conducted specifically for REACH.

Test material

Constituent 1
Chemical structure
Reference substance name:
4-[(3-hydroxypropyl)amino]-3-nitrophenol
EC Number:
406-305-9
EC Name:
4-[(3-hydroxypropyl)amino]-3-nitrophenol
Cas Number:
92952-81-3
Molecular formula:
C9H12N2O4
IUPAC Name:
4-[(3-hydroxypropyl)amino]-3-nitrophenol

In vivo test system

Test animals

Species:
guinea pig
Strain:
Dunkin-Hartley
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
other: dermal
Vehicle:
other: distilled water
Concentration / amount:
Intradermal induction : 10 w/v% in distilled water
Dermal induction : 50% w/v% in distilled water
Concentration of test material and vehicle used for each challenge : 25% w/v% in distilled water
Challengeopen allclose all
Route:
other: dermal
Vehicle:
other: distilled water
Concentration / amount:
Intradermal induction : 10 w/v% in distilled water
Dermal induction : 50% w/v% in distilled water
Concentration of test material and vehicle used for each challenge : 25% w/v% in distilled water
Positive control substance(s):
not specified

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
%
No. with + reactions:
2
Total no. in group:
20
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: %. No with. + reactions: 2.0. Total no. in groups: 20.0.
Reading:
2nd reading
Hours after challenge:
48
Group:
test chemical
Dose level:
%
No. with + reactions:
3
Total no. in group:
20
Remarks on result:
other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: %. No with. + reactions: 3.0. Total no. in groups: 20.0.
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
%
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: %. No with. + reactions: 0.0. Total no. in groups: 10.0.
Reading:
2nd reading
Hours after challenge:
48
Group:
negative control
Dose level:
%
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: %. No with. + reactions: 0.0. Total no. in groups: 10.0.

Applicant's summary and conclusion

Interpretation of results:
other: not classified
Conclusions:
Substance not classified as a skin sensitiser.