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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Information from migrated NONS file as per inquiry # [06-0000024522-76-0000], permission to refer granted by ECHA
Title:
Unnamed
Year:
1991
Report date:
1991

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG, B.4; OECD 404
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
4-[(3-hydroxypropyl)amino]-3-nitrophenol
EC Number:
406-305-9
EC Name:
4-[(3-hydroxypropyl)amino]-3-nitrophenol
Cas Number:
92952-81-3
Molecular formula:
C9H12N2O4
IUPAC Name:
4-[(3-hydroxypropyl)amino]-3-nitrophenol

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
semiocclusive
Preparation of test site:
not specified
Vehicle:
other: Distilled water
Controls:
not specified
Amount / concentration applied:
500 mg
Duration of treatment / exposure:
4 hr
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
animal #1
Time point:
other: overall at 24, 48 and 72 hr
Score:
3
Irritation parameter:
edema score
Basis:
animal #2
Time point:
other: overall at 24, 48 and 72 hr
Score:
2
Irritation parameter:
edema score
Basis:
animal #3
Time point:
other: overall at 24, 48 and 72 hr
Score:
1.7
Irritation parameter:
edema score
Max. score:
3
Remarks on result:
other: Max. duration: d; Max. value at end of observation period 0 (related to all animals)
Irritant / corrosive response data:
Reversibility of any observed effect : Changes fully reversible within 14 days.
Other effects:
Skinfold thickness : the sites of application revealed an increased skinfold thickness among all of the animals after 24 h up to 7 days p.a. 14 days p.a. only 2 out of the 3 test animals still exhibited a slightly increased skinfold thickness.

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance was classified as irritating to the skin.