Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 426-200-1 | CAS number: 172015-79-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Guidance on Safe Use
Administrative data
First-aid measures
Emergency measure - Inhalation: Remove to fresh air. Symptomatic treatment. Obtain
immediate medical attention.
Emergency measure - Eyes: Wash thoroughly with water and continue for at least 15 minutes. Seek medical attention.
Emergency measure - Skin: Remove contaminated clothing and launder before reuse.
Thoroughly wash all affected areas with soap and water. Seek medical attention.
Emergency measure - Ingestion: Seek immediate medical attention.
Fire-fighting measures
Recommended extinguishing agent: Water, foam, powder or carbon dioxide.
Product arising from burning: Noxious fumes (eg carbon and nitrogen oxides and chlorine
containing compounds).
Product determined by test: N
Protective equipment: Full protective clothing and a self-contained breathing apparatus must be worn.
Accidental release measures
Emergency measures in case of spillage: Ensure suitable protective clothing during removal of
spillages.
Damp down and sweep up into a container for disposal. Wash the spillage area with water.
Disposal should be in accordance with local, state or national legislation.
Handling and storage
Handling: The substance should be stored, handled and used under
conditions of good industrial hygiene and in conformity with
any local regulations in order to avoid exposure by skin and eye contact, ingestion and inhalation.
Storage: Keep container tightly closed in a cool dry place.
Packaging of the substance and or preparation: Polythene lined fibre board kegs.
Transport information
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Marine transport (UN RTDG/IMDG)
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Air transport (UN RTDG/ICAO/IATA)
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Special provisions / remarks
- Remarks:
- Transport code: None
Transport: Avoid crushing the containers.
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Exposure controls / personal protection
Occupational Hygiene Air
Monitoring Methods
An occupational/industrial hygiene monitoring method has been developed for this material. For
advice on suitable monitoring methods, seek guidance from a qualified environment, health and
safety professional.
ENGINEERING CONTROLS
Exposure Controls
This material has been assigned to GlaxoSmithKline Occupational Hazard Category 3 with a
hygiene guide of 10 - <100 mcg/m3. An Exposure Control Approach (ECA) is established for
operations involving this material based upon the OEL/Occupational Hazard Category and the
outcome of a site- or operation-specific risk assessment. Refer to the Exposure Control Matrix for
more information about how ECA's are assigned and how to interpret them.
Containment
Open handling is not recommended. Consider segregating operations, use of enclosures and
sealed transfer systems.
Ventilation
Local exhaust ventilation (LEV) should be used in conjunction with other control measures as a
means of removing material incidentally released.
Administrative
Entry to the working area should be controlled. Doors with interlocks may be needed for materials
airlocks and locker rooms. Only equipment and supplies necessary for job activities should be
taken into working area.
PERSONAL PROTECTIVE EQUIPMENT
Eye Protection
Wear approved cover goggles if eye contact is possible. In addition, a face shield is
recommended.
Gloves
The selection of gloves for a specific activity must be based on the material's properties and on
possible permeation and degradation that may occur under the circumstances of use. Glove
selection must take into account any solvents and other hazards present. Potential allergic
reactions can occur with certain glove materials (e.g. Latex) and therefore these should be
avoided. Care must be exercised if insufficient data are available and further guidance should be
sought from your local EHS department.
Respirators
If respiratory protective equipment (RPE) is used, the type of RPE will depend upon air
concentrations present, required protection factor as well as hazards, physical properties and
warning properties of substances present. RPE should provide full face protection. Follow local
regulations for respirator use in the workplace.
Other Equipment or
Procedures
Consider control procedures for maintenance, cleaning and emergencies. Eye wash and shower
stations should be available. Wear appropriate clothing to avoid skin contact.
Stability and reactivity
Danger other than fire: None reported.
Chemical reaction with water: None reported.
Dust explosion: There is a potential for dust explosion of this organic
powder when it becomes airbourne. However, appropriate
handling and storage procedures are used to minimise the risk of electrostatic discharge.
Dust explosion determined by test: N
Disposal considerations
Industry - Possibility of recovery/recycling: Handling of the substance will be by trained operators, and
will be kept to a minimum.
Discharge to the environment will be minimal. Recovery from minor spillages or accidental discharge is not economically
or technically feasible, and such waste material wiil be
disposed of by incineration. In principle, it may be possible to recover larger spillages of uncontaminated
material for subsequent use.
Industry - Possibility of neutralisation: The notification tests have shown that the substance is
toxic, an eye irritant, a skin sensitiser and dangerous for
the environment.
No chemical treatment is practicable to neutralise the
hazardous health properties.
The potential dust storage hazard will be minimised by
appropriate handling and storage.
No chemical treatment is practicable to neutralise the
hazardous environmental properties.
Industry - Possibility of destruction: controlled discharge: Contaminated containers or spillages of solutions mixed with
inert material (eg. sand or soil) should be disposed of by
incineration in accordance with local regulations.
Industry - Possibility of destruction - incineration: The substance can be disposed of by incineration by burning
under controlled conditions at a licensed waste treatment
processor in accordance with local regulations. Stack gases should be scrubbed, because noxious fumes (eg. carbon and
nitrogen oxides and chlorine-containing compounds) could be
formed.
Industry - Possibility of destruction - water purification: The substance will not normally be discharged directly to the sewage system or the aqueous environment.
Public at large - Possibility of recovery/recycling: Not applicable
Public at large - Possibility of neutralisation: Not applicable
Public at large - Possibility of destruction: controlled discharge: Not applicable
Public at large - Possibility of destruction - incineration: Not applicable
Public at large - Possibility of destruction - water purification: Not applicable
Public at large - Possibility of destruction - others: Not applicable
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

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