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Diss Factsheets
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EC number: 930-776-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The group size is not defined, an thus the study and its statistical basis cannot be evaluated
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of chronic manganese (Mn3O4) exposure on selected reproductive parameters in rats
- Author:
- Laskey JW, Rehnberg GL, Hein JF & Carter SD
- Year:
- 1 982
- Bibliographic source:
- Journal of Toxicology and Environmental Health, 9: 677-687
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Long-Evans rats were chronically exposed to Mn3O4 (in diet) at 0, 350, 1050 and 3500 ppm from day 1 of gestation up to 224 days of age. Rats were grouped into either low or normal Fe dietary levels. Reproductive development and fertility of the F1 generation were determined.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Silicomanganese manufacturing fumes dedusting solid residues
- EC Number:
- 930-776-4
- IUPAC Name:
- Silicomanganese manufacturing fumes dedusting solid residues
- Details on test material:
- - Name of test material : Mn3O4 (trimanganese tetraoxide)
- Analytical purity: 98 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Long-Evans
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Details on mating procedure:
- - Impregnation procedure: co-housed
- If co-housed:
- M/F ratio per cage: 1:2
- Length of cohabitation: 2 weeks - Duration of treatment / exposure:
- Pregnant females were exposed to Mn3O4 in diet from day 2 of pregnancy until weaning of the offspring. Offspring were further exposed and mated at day 90-100. Treatment continued until the end of the study, 224 days.
- Frequency of treatment:
- Daily
- Duration of test:
- Up to 224 days of age
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 350, 1050 and 3500 ppm
Basis:
nominal conc.
- No. of animals per sex per dose:
- Not reported
- Control animals:
- yes, plain diet
Results and discussion
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Any other information on results incl. tables
General toxic effects were apparent in young animals at a dietary dose of 3500 ppm Mn and were enhanced by concomitant Fe deficiency. Fertility was reduced in the group exposed to 3500 ppm Mn with a diet containing sufficient Fe. Male reproductive development was delayed by Mn treatment, as measured by testes weight, sperm count, and serum follicle-stimulating hormone and testosterone concentrations.
Applicant's summary and conclusion
- Conclusions:
- The study cannot be evaluated as no information on group size is given, and thus validity of the statistics cannot be guaranteed.
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