Registration Dossier
Registration Dossier
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EC number: 223-069-0 | CAS number: 3720-16-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No sensitisation was observed in the "Skin irritation and capacity for allergic sensitization determined by the open epicutaneous test (OET)" on guinea pigs at 3, 10, 30 or 100%. The 4 reaction out of 74 subjects tested by Epstein (1981 -1985) were all compromised by irritation affects. In the absence of irritation, no sensitisation affects were observed. Therefore it is concluded that the 4 subject positive reactions were not true sensitisation affects.
Migrated from Short description of key information:
Negative guinea pig OET and questionable positive reactions in 4 out of 74 subjects that were compromised by irritiation affects.
Justification for selection of skin sensitisation endpoint:
Guinea pig OET and Human data.
Justification for classification or non-classification
Negative guinea pig OET and questionable positive reactions in 4 out of 74 subjects that were compromised by irritiation affects.
No positives reactions in the absence of irritation.
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