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EC number: 282-968-6 | CAS number: 84501-49-5
21d NOEC (D. magna, reproduction) = 1.4 mg/L (measured concentration, OECD 211)
Since no reliable chronic test involving aquatic invertebrates is available for C9-11AS Na (CAS 84501-49-5), in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5, a read-across to other structurally related category members was conducted. Read-across data from the following substances were used: C10AS Na (CAS 142-87-0) and C12AS Na (CAS 151-21-3), since toxicity of alkyl sulfates is dependent on the carbon chain length.
One key long-term toxicity study with Daphnia magna is available for C10AS Na (CAS 142-87-0; BASF 2012). The test was performed according to OECD 211 guideline and GLP principles. Daphnids were exposed for 21 days under semi-static conditions to six test concentrations up to 6.86 mg/L (measured concentration). The followed parameters included mortality and reproduction of daphnids. The NOEC value based on the reproduction was determined to be 1.4 mg/L and the LOEC value as 6.86 mg/L (measured concentrations).
A supporting non-GLP, 7-day reproduction toxicity test with Ceriodaphnia dubia performed according to EPA-600/489/001 guideline is available for C12AS Na (CAS 151-21-3; Lauth 1996). Daphnids were exposed under flow-through conditions to five test concentrations up to 8 mg/L. Analytical check of test concentration proved that the nominal concentrations were in agreement with the measured ones. Mortality and reproduction were evaluated daily. The NOEC value determined after 7 days of exposure to test substance was 0.88 mg/L (measured concentration). The results of this test are provided for the read-across purpose, but since they are too conservative, they are not used as a key-value for C9 -11AS Na (CAS 84501-49-5).
Moreover, a supporting publication from LeBlanc (1982) is available for C12AS Na (CAS 151-21-3). In this non-GLP, 40-day test Daphnia magna was exposed to CAS 151-21-3 up to 8 mg/L (nominal concentration) over four consecutive generations under semi-static conditions. No special guideline was followed. Offspring daphnids of less than 24 hours of age were collected after 10 days of exposure to the test substance and exposed for another 10 days. This procedure was repeated three times. The overall NOEC ranged from 2 to 4 mg/L (nominal concentrations, analytics not performed).
Due to structural and property similarities with the tested category member these results also can be used to determine the long-term toxicity to aquatic invertebrates of C9-11AS Na (CAS 84501-49-5). The results for C10AS Na (CAS 142-87-0) are judged to be the most representative and therefore the NOEC of 1.4 mg/L is considered as a key value for C9-11AS Na (CAS 84501-49-5).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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