Registration Dossier
Registration Dossier
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EC number: 942-066-1 | CAS number: -
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21d) >= 10 mg/L (nominal loading rate) for Daphnia magna (OECD 211, read across)
Key value for chemical safety assessment
Additional information
Since no study assessing the long-term toxicity of Reaction mass of bis(2-propylheptyl) hexanedioate and O6-[2,2-bis[[6-oxo-6-(2-propylheptoxy)hexanoyl]oxymethyl]butyl] O1-(2-propylheptyl) hexanedioate to aquatic invertebrates is available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 Grouping of substances, a read-across to the source substance Bis(2-propylheptyl) adipate (940-510-9, DPHA) was conducted. The read across is justified since DPHA is the main constituent (80%) of the target substance. The high molecular weight (> 900 g/mole) and log Pow (> 10) of the TMP ester constituent indicate a much lower toxicity of this constituent compared to DPHA. Thus, the study result for the source substance is considered to adequately cover the aquatic toxicity of the whole multi-constituent substance.
The long-term toxicity of Bis(2-propylheptyl) hexanedioate to aquatic invertebrates was performed according to GLP and OECD guideline 211 using Daphnia magna as test organism (BASF 2015). A 10 mg/L loading rate was tested as limit test. All validity criteria are fulfilled. No effects on adult survival and reproductive output was observed in the treatment compared to the control. Thus, the 21d-NOEC is determined to be >= 10 mg/L based on the nominal concentration. Based on this result Reaction mass of bis(2-propylheptyl) hexanedioate and O6-[2,2-bis[[6-oxo-6-(2-propylheptoxy)hexanoyl]oxymethyl]butyl] O1-(2-propylheptyl) hexanedioate is considered to be not harmful to aquatic invertebrates at chronic exposure.
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