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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
See IUCLID section 13 for category and read across justification

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of study:
activation of keratinocytes

Test material

Constituent 1
Chemical structure
Reference substance name:
Lithium myristate
EC Number:
243-743-8
EC Name:
Lithium myristate
Cas Number:
20336-96-3
Molecular formula:
C14H28O2.Li
IUPAC Name:
lithium myristate
impurity 1
Chemical structure
Reference substance name:
Lithium laurate
EC Number:
238-663-5
EC Name:
Lithium laurate
Cas Number:
14622-13-0
Molecular formula:
C12H24O2.Li
IUPAC Name:
lithium laurate
impurity 2
Chemical structure
Reference substance name:
Lithium palmitate
EC Number:
243-842-6
EC Name:
Lithium palmitate
Cas Number:
20466-33-5
Molecular formula:
C16H32O2.Li
IUPAC Name:
lithium palmitate
impurity 3
Chemical structure
Reference substance name:
Lithium hydroxide
EC Number:
215-183-4
EC Name:
Lithium hydroxide
Cas Number:
1310-65-2
Molecular formula:
HLiO
IUPAC Name:
lithium hydroxide
Test material form:
solid
Details on test material:
- Batch number: A194-99/3
- Expiry date: 02 April 2022

Results and discussion

In vitro / in chemico

Results
Key result
Remarks on result:
other: Test currently ongoing
Remarks:
Test currently ongoing

Applicant's summary and conclusion

Interpretation of results:
other:
Remarks:
Test currently ongoing
Conclusions:
The skin sensitisation potential of lithium myristate was determined to be
Executive summary:

The skin sensitisation potential of lithium myristate in the in vitro OECD 442D Keratinosens test was determined to be