Registration Dossier

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

The acute toxicities of lithium myristate, lithium 12-hydroxystearate and lithium behenate to Daphnia showed no effects at a water accommodated fraction loading rate of 100 mg/L. Therefore, the 48 hour EL50 is determined to be > 100 mg/L WAF for all three substances.

Key value for chemical safety assessment

Additional information

The acute toxicities to Daphnia were determined in GLP-compliant, limit tests (Harlan 2013) following OECD guideline 202. As no effects were observed in the preliminary range finding tests, the definitive toxicity to Daphnia tests were all conducted as limit tests at 100 mg/L alongside a blank control. Twenty Daphnia divided into four replicates were exposed to water accommodated fractions of lithium myristate, lithium 12-hydroxystearate and lithium behenate for 48 hours in standard ecotoxicity media adjusted to a hardness of approximately 150 mg/L CaCO3. Observations of immobilisation or abnormalities of behaviour or appearance of the Daphnia were made at 24 and 48 hours and the test solutions analysed for lithium content and total organic carbon at test initiation and termination.

Lithium myristate, the shortest carbon chain length substance in the category, lithium 12-hydroxysterate, with intermediate carbon chain length, and lithium behenate, the longest carbon chain length substance in the category, all have 48 hour EL50s of >100 mg/L WAF to Daphnia. As none of these substances are acutely toxic to Daphnia, it can be justifiably expected that the remaining substances in the category with intervening carbon chain lengths will not be acutely toxic to Daphnia either.