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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline available
Guideline:
other: no data
GLP compliance:
no
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium 4-(2-hydroxynaphth-1-ylazo)-3-methylbenzenesulphonate
EC Number:
227-458-6
EC Name:
Sodium 4-(2-hydroxynaphth-1-ylazo)-3-methylbenzenesulphonate
Cas Number:
5850-86-2
Molecular formula:
C17H14N2O4S.Na
IUPAC Name:
sodium 4-(2-hydroxynaphth-1-ylazo)-3-methylbenzenesulphonate

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
CMC (carboxymethyl cellulose)
Details on dermal exposure:
50% suspension in a 0.5% aqueous carboxymethyl cellulose preparation

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 500 mg/kg bw
Based on:
test mat.
Mortality:
No mortality
Clinical signs:
No abnormalities
Gross pathology:
No abnormalities

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The tested item was found to be non-toxic for dermal exposure with a LD50 > 2500 mg/kg bw.
Executive summary:

The acute dermal toxicity of the tested substance in rats was assessed with this test and the LD50 value was > 2500 mg/kg.

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