Phenol, 4-[(1E,3S)-3-ethenyl-3,7-dimethyl-1,6-octadien-1-yl]-

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2009

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dien-1-yl]phenol

EC Number:

685-515-4

Cas Number:

10309-37-2

Molecular formula:

C18H24O

IUPAC Name:

4-[(1E,3S)-3-ethenyl-3,7-dimethylocta-1,6-dien-1-yl]phenol

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 8-12 weeks
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 d

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19.5 - 22.1
- Humidity (%): 55 - 60
- Photoperiod (hrs dark / hrs light): 12 h light and 12 h dark

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Doses:

dose volumn: 10ml/Kg bw
dose level: 2000 mg/kg bw

No. of animals per sex per dose:

6 (2 steps, three animals per step)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 1/2, 1, 2, 4 h after dosing, thereafter, once daily.
- Necropsy of survivors performed: yes
In step - 1, three overnight fasted animals were administered with 2000 mglkg bw.
ln step-2, to confirm the above dose level three more overnight fasted female animals were administered 2000 mg/kg bw.
- Other examinations performed: clinical signs, body weight.

Results and discussion

Effect levels

Sex:

female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Based on:

test mat.

Mortality:

In step 1, no mortality.
In step 2, one mortality on 3th day

Clinical signs:

other: In step 1, no clinical signs In step 2, one exhibited clinical signs of toxicity such as piloerection and dullness on day 1 &2, and died on day 3. The other two animals did not exhibit any clinical signs of toxicity during the entire observation period

Gross pathology:

Gross pathology examination conducted on the animals died during observation period and survived animals on day 14 did not reveal any lesion that could be attributed for the administration of the test substance

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU