Pyridoxine hydrochloride

Flammability

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

flammability

Type of information:

other: statement

Adequacy of study:

key study

Study period:

04 December 2014-09 April 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-compliant statement in accordance with UN-MTC Appendix 6. In accordance with Section 1 of REACH Annex XI, testing was not performed.

Qualifier:

according to guideline

Guideline:

other: UN ST/SG/AC.10/11/Rev.5: Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, Appendix 6 "Screening procedures" (2009)

Deviations:

no

GLP compliance:

yes

 

A test substance is considered highly flammable when it ignites spontaneously in contact with water, or evolves a flammable gas at a minimum rate of ≥ 1 L/kg of the substance per hour.

 

The molecular structure of the test substance does not contain groups that might lead to ignition in contact with water and/or to the evolution of a flammable gas. Moreover the test substance was dissolved in water during the determination of the water solubility. It demonstrated that the test substance does not ignite spontaneously in contact with water.

Interpretation of results:

other: not highly flammable in contact with water

Conclusions:

From a GLP-compliant statement based on structural features and experience in handling, it was concluded that the substance is not highly flammable in contact with water.

Reference 2

Endpoint:

flammable solids

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04 December 2014-09 April 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-compliant study in accordance with UN-MTC Section 33.2.1 and EC A.10.

Qualifier:

according to guideline

Guideline:

other: UN ST/SG/AC.10/11/Rev.5: Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, Part III Section 33.2.1 "Flammable solids" (2009)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.10 (Flammability (Solids))

Version / remarks:

(2008)

Deviations:

no

Principles of method if other than guideline:

UN MTC Section 33.2.1.4 - Test N.1: Test method for readily combustible solids.

GLP compliance:

yes

Test procedure:

burning time (test type not further specified)

Remarks on result:

other: The substance does not popagate combustion along 200 mm length of the pile within 4 minutes.

The flame from the gas burner did ignite the test substance pile. The test substance melted, glowed, expanded, burned with a blue yellow flame, and turned into a black residue. White smoke was observed. After removal of the ignition source, the flame extinguished immediately and no propagation of combustion was observed.

Interpretation of results:

other: 'not highly flammable' by ignition

Conclusions:

In a GLP-compliant study performed in accordance with UN-MTC Section 33.2.1 (Test N.1) and EC A.10, the substance has been determined to be 'not highly flammable' by ignition.

Reference 3

Endpoint:

flammability

Type of information:

other: statement

Adequacy of study:

key study

Study period:

04 December 2014-09 April 2015

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP-compliant statement in accordance with UN-MTC Appendix 6. In accordance with Section 1 of REACH Annex XI, testing was not performed.

Qualifier:

according to guideline

Guideline:

other: UN ST/SG/AC.10/11/Rev.5: Recommendations on the Transport of Dangerous Goods, Manual of Tests and Criteria, Appendix 6 "Screening procedures" (2009)

Deviations:

no

GLP compliance:

yes

A test substance is considered pyrophoric when it ignites within five minutes of coming in contact with air.

 

The molecular structure of the test substance does not contain groups that might lead to ignition in contact with air. Moreover the test substance was handled under normal laboratory conditions during the determination of the physico-chemical properties. It demonstrated that the test substance does not ignite in contact with air.

Interpretation of results:

other: no pyrophoric properties

Conclusions:

From a GLP-compliant statement based on structural features and experience in handling, it was concluded that the substance has no pyrophoric properties.

Description of key information

Flammability.solid - The substance does not propagate combustion along 200 mm length of the pile within 4 minutes. The flame from the gas burner did ignite the test substance pile. The test substance melted, glowed, expanded, burned with a blue yellow flame, and turned into a black residue. White smoke was observed. After removal of the ignition source, the flame extinguished immediately and no propagation of combustion was observed. In a GLP-compliant study performed in accordance with UN-MTC Section 33.2.1 (Test N.1) and EC A.10, the substance has been determined to be 'not highly flammable' by ignition.

Fammability contact with water - A test substance is considered highly flammable when it ignites spontaneously in contact with water, or evolves a flammable gas at a minimum rate of ≥ 1 L/kg of the substance per hour. The molecular structure of the test substance does not contain groups that might lead to ignition in contact with water and/or to the evolution of a flammable gas. Moreover the test substance was dissolved in water during the determination of the water solubility. It demonstrated that the test substance does not ignite spontaneously in contact with water. From a GLP-compliant statement based on structural features and experience in handling, it was concluded that the substance is not highly flammable in contact with water.

Pyrophoric properties -  A test substance is considered pyrophoric when it ignites within five minutes of coming in contact with air. The molecular structure of the test substance does not contain groups that might lead to ignition in contact with air. Moreover the test substance was handled under normal laboratory conditions during the determination of the physico-chemical properties. It demonstrated that the test substance does not ignite in contact with air. From a GLP-compliant statement based on structural features and experience in handling, it was concluded that the substance has no pyrophoric properties.

Key value for chemical safety assessment

Flammability:

not classified

Justification for classification or non-classification

The test material has been determined to be not highly flammable as it did not propagate combustion over the 200 mm of the preliminary screening test.