Registration Dossier
Registration Dossier
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EC number: 292-835-4 | CAS number: 91001-64-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
No specific study was performed on the absorption, distribution, metabolism and/or excretion (ADME) of WS400109, a complex mixture of components. In general, absorption and systemic availability of WS400109 after oral or topical administration are expected to be limited, because of its low water solubility, rather high lipohilicity (for ca. 80% by chromatographic area Log10Pow> 4.1) and, to some extent, its molecular weight (ca. 370 – 900). However, some absorption and systemic availability of WS400109 cannot be entirely discounted, because a number of its components may have a partition coefficient value Log10Pow ≤ 4.1 and/or for some the molecular weight is only moderate, i.e. ca. 100 or ca. 370 to < 500. Effects clearly indicative of absorption and systemic availability of WS400109, components or metabolites of it have not been evident after oral administration to rodents. However, some dermal absorption after topical administration has been concluded from an irritation response (increased ear thickness) to undiluted WS400109 and from a dose-related sensitization response to non-irritating test concentrations attained in a Local Lymph Node Assay (LLNA) in mice.
Exposure of humans to vapour of WS400109 by the inhalation route is unlikely, because of its low vapour pressure (7 x 10-3Pa at 25°C) and decomposition at high temperature without boiling (> ca. 215°C). Its availability as an inhalable aerosol may be unlikely, because it is a viscous liquid (viscosity medium in degree).
All available study results gave no indication regarding the metabolic pathway, distribution or excretion of WS400109. Bioaccumulation was not investigated.
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