Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

No experimental data available.

Key value for chemical safety assessment

Additional information

No data are available on toxicokinetics, metabolism and distribution of the substance by the oral, dermal or inhalation routes.

The test material is a liquid that is not considered to be volatile because of the low vapour pressure value (<0.01 Pa (mean) 31 -36°C). The test material is expected to hydrolyse under physiological conditions.

Absorption: The results of the acute and repeat-dose oral toxicity studies in the rat show no evidence of significant systemic toxicity. It is likely that the test material is rapidly hydrolysed in the gastro-intestinal tract prior to absorption. This does not rule out absorption of the degradants.The physical characteristics of the parent material such as the lack of ionisable groups and moderately low molecular weight, would allow the material to be absorbed from the gastro-intestinal tract.  

There is no evidence of systemic toxicity following acute dermal exposure to rats. This may be the result of the low inherent toxicity of the material or the test material is not absorbed.

Distribution:There is no evidence to indicate if the test material is distributed systemically.

Metabolism: The test material hydrolyses under physiological conditions, which suggests that it is susceptible to the action of non-specific hydrolase activity. There is no evidence to suggest that significant hepatic metabolism is involved. The result of an in vitro genotoxicity assay shows no enhanced or diminished activity in the presence of S9 metabolising system.

Excretion:There is no evidence to indicate the route of excretion but it is most likely that the kidney is the principal route for absorbed material. Any
unabsorbed test material will be excreted in the faeces.