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Diss Factsheets

Administrative data

Endpoint:
skin sensitisation: in vivo (LLNA)
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2010
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
GLP compliance:
yes (incl. QA statement)
Type of study:
mouse local lymph node assay (LLNA)

Test material

Constituent 1
Chemical structure
Reference substance name:
(4Z)-hept-4-en-2-yl salicylate
EC Number:
700-488-1
Cas Number:
873888-84-7
Molecular formula:
C14H18O3
IUPAC Name:
(4Z)-hept-4-en-2-yl salicylate

In vivo test system

Test animals

Species:
mouse
Strain:
other: CBA/J
Sex:
not specified

Study design: in vivo (LLNA)

Vehicle:
acetone/olive oil (4:1 v/v)
Concentration:
25, 50 and 100%
No. of animals per dose:
2

Results and discussion

In vivo (LLNA)

Resultsopen allclose all
Parameter:
SI
Remarks on result:
other: 25%= 2.4 50%= 4.9 100%= 9.7
Parameter:
other: disintegrations per minute (DPM)
Remarks on result:
other: No data

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information
Conclusions:
EC3= 13.8%

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