Registration Dossier
Registration Dossier
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EC number: 304-802-4 | CAS number: 94279-56-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: Assessment
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Expert assessment as opposed to experimental result
Data source
Reference
- Reference Type:
- other: Expert Assessment
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
- Principles of method if other than guideline:
- Assessment
- GLP compliance:
- no
Test material
- Reference substance name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- EC Number:
- 304-802-4
- EC Name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- Cas Number:
- 94279-56-8
- Molecular formula:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- IUPAC Name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
Constituent 1
Results and discussion
In vitro
Results
- Remarks on result:
- other: The substance in water has a pH of >13 due to the presence of residual sodium hydroxide and would be highly corrosive to eyes due to the residual alkali; testing would not be required to show this as the properties of sodium hydroxide are well-known
Any other information on results incl. tables
Assessment
Applicant's summary and conclusion
- Interpretation of results:
- Category 2A (irritating to eyes) based on GHS criteria
- Remarks:
- Migrated information
- Executive summary:
This substance is the product of a reaction between Zircon (EC no 239-019-6) and sodium hydroxide. The substance i water has a pH of >13 due to the presence of significant amounts of residual sodium hydroxide. The UVCB substance as produced would be highly damaging to eyes due to the residual alkali; testing would not be required to demonstrate this is the properties of sodium hydroxide are well-known. In vivo testing of the substance would be inappropriate on animal welfare grounds, and such testing for substances where the pH is >11 is prohibited. The substance is classified based on this as skin corrosion/irritation, category 1A (H314), i.e. corrosive. Disodium metasilicate (229-912-9) has been tested for eye irritancy as have a number of zirconium salts. None of these would contribute at all to the corrosiveness due to the sodium hydroxide present in this substance.
The above should be considered as an expert statement to waive the requirement for testing for eye irritation in REACH Annex VIII for endpoint 8.2.1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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