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EC number: 304-802-4 | CAS number: 94279-56-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1992/11/06 to 1993/02/18
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Old study, the report is not as detailed as would now be expected (for example test material details). Minor deficiencies such as bodyweight recordings missed.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- other: LD50
- Limit test:
- yes
Test material
- Reference substance name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- EC Number:
- 304-802-4
- EC Name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- Cas Number:
- 94279-56-8
- Molecular formula:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- IUPAC Name:
- Silicic acid (H4SiO4), zirconium(4+) salt (1:1), reaction products with sodium hydroxide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Olac Limited
- Age at study initiation: 6-8 weeks old
- Weight at study initiation: 106-207g
- Fasting period before study: overnight
- Housing: polypropylene cages with mesh floors
- Diet (e.g. ad libitum): ad libitum except for overnight before dosing and 4 hour after dosing
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-21
- Humidity (%): 50
- Air changes (per hr): 15-20
- Photoperiod (hrs dark / hrs light): 12 / 12
IN-LIFE DATES: From: To: 1992/12/02 to 1993/02/18
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
- Doses:
- 2000 mg/kg (limit test)
1000, 1400, 1800, 2200 (LD50) - No. of animals per sex per dose:
- 5 males and 5 females per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: prior to dosing, 7 days and at death or end of study (14 days)
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, - Statistics:
- Finney (1971) and Berson (1953)
Results and discussion
- Preliminary study:
- 4 out of 5 male rats and 3 out of 5 female rats died at 2000 mg/kg
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 387 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 529 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 372 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Dose level (mg/kg)
1000 (0/5 male and 4/5 female)
1400 (3/5 male and 0/5 female)
1800 (5/5 male and 1/5 female)
2200 (5/5 male and 5/5 female) - Clinical signs:
- other: noted 1 min to 3 days after dosing: piloerection, soiled coat, watery ocular discharge, subdued behaviour, prostration, tremors, hunched appearance, low body temperature, laboured breathing, increased salivation and activity, ataxia and pale extremities
- Gross pathology:
- In premature decedents only: these were confined to the mucosal surfaces of the stomach which were noted to be dark red in appearance. In additional and area of ulceration of the mucosal surface was observed in one animal.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The estimated LD50 is 1372 mg/kg bw for males and females
- Executive summary:
Following a single orally administered dose of Frit (10 mL/kg in maize oil) at a dose level of 2000 mg/kg bw, 4 of the 5 male Sprague Dawley rats and 3 of the 5 female Sprague Dawley rats died. A further 4 dose levels of 1000, 1400, 1800 and 2200 mg/kg bw were selected to determine the LD50 value. In the LD50 test, deaths occurred 4h to 4 days after dosing.
Clinical signs, noted 1 min to 3 days after dosing, included piloerection, soiled coat, watery ocular discharge, subdued behaviour, prostration, tremors, hunched appearance, low body temperature, laboured breathing, increased salivation and activity, ataxia and pale extremities.
Necropsy findings, in premature decedents only, were confined to the mucosal surfaces of the stomach which were noted to be dark red in appearance. In additional and area of ulceration of the mucosal surface was observed in one animal.
The Median Oral Lethal Doses (LD50s) and 95% confidence intervals of Frit for male and female rats are estimated to be:
Males 1387 mg/kg
Females 1529 mg/kg
Males and Females 1372 (937 -1721) mg/kg
Note - no confidence intervals can be given for the male and female LD50 values due to the spread of the fractional mortality data
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