Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP study according EU/OECD guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report Date:
2013

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
GLP compliance:
yes (incl. certificate)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
3.235
Temp.:
23 °C
pH:
6.98
Remarks on result:
other: Exp. 1A
Type:
Pow
Partition coefficient:
3.287
Temp.:
23 °C
pH:
6.93
Remarks on result:
other: Exp. 1B
Type:
Pow
Partition coefficient:
3.143
Temp.:
23 °C
pH:
6.83
Remarks on result:
other: Exp. 2A
Type:
Pow
Partition coefficient:
3.039
Temp.:
23 °C
pH:
6.82
Remarks on result:
other: Exp. 2B
Type:
Pow
Partition coefficient:
3.145
Temp.:
23 °C
pH:
6.84
Remarks on result:
other: Exp. 3A
Type:
Pow
Partition coefficient:
3.089
Temp.:
23 °C
pH:
6.82
Remarks on result:
other: Exp. 3B
Type:
Pow
Partition coefficient:
3.261
Temp.:
23 °C
pH:
> 6.9
Remarks on result:
other: Average Pow Exp. 1A+B
Type:
Pow
Partition coefficient:
3.091
Temp.:
23 °C
pH:
> 6.8
Remarks on result:
other: Average Pow Exp. 2A+B
Type:
Pow
Partition coefficient:
3.117
Temp.:
23 °C
pH:
> 6.8
Remarks on result:
other: Average Pow Exp. 3A+B

Any other information on results incl. tables

Type  Partition coefficient  Temp. / °C  pH  Remarks
log Pow  0.51 23 > 6.9 Average Exp. 1
log Pow  0.49 23 > 6.8  Average Exp. 2
log Pow  0.49 23 > 6.8  Average Exp. 3
Pow 3.156 23 6.9 mean result
log Pow 0.5 23 6.9 mean result

Applicant's summary and conclusion

Conclusions:
The partition coefficient of the test item at 23 °C, at pH 6.9 was Pow = 3.156, log Pow = 0.5.