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EC number: 276-481-8
CAS number: 72214-18-7
A sensitization test in albino guinea pigs
was performed to determine the contact allergenic potency of FAT 41001/F
in albino guinea pigs. This test was based on the OECD Guideline No. 406
and GLP. In a pre-test conducted for assessment of irritation potential,
no skin irritation was observed. Therefore, the application site was
pretreated with 10% sodium-lauryl sulfate (open application) 24 hours
prior to the epidermal induction application. The concentration of 5%
was selected for induction (day 0) and 50% was selected for epidermal
induction (7 days) and epidermal challenge (5 weeks). The incidence of
positive animals per group, the individual challenge reactions and the
evaluation of the primary skin irritation potential was carried
according to grading of Magnusson and Kligman.
Under the experimental conditions employed,
100 and 90% of the animals of the test group showed skin reactions 24
and 48 hours after removing the dressings, respectively. No abnormality
in increase of body weight was observed in test animals. According to
the maximization grading FAT 41001/F showed an extreme grade of
skin-sensitizing (contact allergenic) potential in albino guinea pigs.
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