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EC number: 276-481-8
CAS number: 72214-18-7
Based on experimental data, Reactive Blue
049 can be concluded to be not readily biodegradable and stable in the
According to the screening criteria for
bioaccumulation (B for bioaccumulative, vB for very bioaccumulative)
given in the technical guidance provided by ECHA (ECHA 2008, Guidance on
information requirements and chemical safety assessment, Chapter R.11),
a substance does not fulfil the B and the vB criterion if its log Kow
≤4.5. The octanol-water partition coefficient for the test item is log
Pow = - 3.88. This value is much below the threshold value of log Kow
≤4.5. Considering the low water solubility and the influence of lipid
solubility on the bioconcentration of hydrophobic compounds
demonstrating a decrease in lipid solubility with increasing Kow values
(Chessells et al. (1992)) for superhydrophobic compounds (log Kow >6),
it can be assumed that it will led to reduced BCFs. In conclusion, the
substance is regarded as not bioaccumulative neither fulfilling the B
nor the vB criterion.
No long-term studies for marine or
freshwater organisms are available. Short term toxicity tests are
available for all the three tropic levels (fish, invertebrate and
aquatic plants). Aquatic acute toxicity studies did not show any effects
up to 100 mg/L. Reactive Blue 049 is not classified for CMR and specific
target organ toxicity on repeated exposure. Therefore, based on current
knowledge, the substance does not fulfil the T criterion based on the
PBT criteria according to Annex XIII of the REACH Regulation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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