Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 608-251-3 | CAS number: 287930-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Oral: evidence presented by the combined 28-day oral toxicity/reproductive toxicity study indicates that the substance is absorbed following administration in aqueous suspension; this is despite of the very low water solubility (0.145 mg/L @pH4) and lipophilic partition co-efficient (4.9). Fetal/embryonic effects( decreased weight gain) also indicate that the substance is readily distributed once absorbed.
Inhalation: Particle size (<45µm) would indicate that the substance is potentially respirable with the low water solubility likely to enhance the penetration to the lower respiratory tract. Given that oral absorption of the substance has been demonstrated in the 28 repeat dose study, it can be expected that absorption by the inhalation route is also likely.
Dermal absorption: based upon the physical properties of water solubility and partition coefficient- dermal uptake is expected to be low, the log Pow would indicate that the absorption to the lipophilic stratum corneum would be high, however the transfer into the epidermis will be low.
Metabolism: evidence from the 28 day study showing hepatocyte hypertrophy as an adaptive change to substance exposure would indicate that the substance is undergoing hepatic metabolism, however the identity of chemical species and extent of biotransformation is unknown.
Excretion: Evidence from the 28-day study, alpha2µglobulin secretion in male kidney, indicates some degree of excretion of the substance or its metabolites.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - dermal (%):
- 10
Additional information
Based upon the results of repeat dose toxicity testing and the physical properties of the substance, it can be predicted that absorption and distribution can be expected by the oral and inhalation routes. Uptake is unlikely by the dermal route, a default value of 10% is assigned based upon the physical properties of the substance. Hepatic and renal effects noted at all dose levels indicate that some degree of metabolism and excretion of the substance is taking place.
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