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Physical & Chemical properties

Partition coefficient

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Administrative data

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
January 29, 2003 - February 6, 2003
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Only 1 reference substance was used and it was observed that a constituent of the substance elutes before this reference substance. Therefore a set of at least 6 reference substances should have been applied to determine the log Kow of this constituent by linear regression analysis. In addition, when the study is conducted in accordance with OECD 117 (2004), it can be investigated whether the log Kow of the other 2 constituents of the substance is between 6 and 10.
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Version / remarks:
(1989)
Deviations:
yes
Remarks:
only 1 reference substance was used and it was observed that a constituent of the substance elutes before this reference substance; therefore a set of at least 6 reference substance should have been applied to determine the log Kow of this constituent
Qualifier:
equivalent or similar to guideline
Guideline:
EU Method A.8 (Partition Coefficient)
Version / remarks:
(1992)
Deviations:
yes
Remarks:
only 1 reference substance was used and it was observed that a constituent of the substance elutes before this reference substance; therefore a set of at least 6 reference substance should have been applied to determine the log Kow of this constituent
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
other: HPLC-UV
Type:
log Pow
Partition coefficient:
>= 6
Temp.:
26 °C
Remarks on result:
other: Result based on comparison with the reference substance 2,4-DDT only. Not determined by linear regression analysis. As the log Pow of 2,4-DDT is 6.3 and 1 of the 3 constituents elutes before this reference substance, it should be used with care.
Details on results:
1 reference substance was used and it was observed that a constituent of the substance eluted before this reference substance. Therefore a set of at least 6 reference substances should have been used to determine the log Kow of this constituent by linear regression analysis.

Preliminary tests

- An n-octanol solubility of < 1 g/L was found

- Calculated values:

Constituent #1: log Pow = 9.25

Constituent #2: log Pow = 14.16

Constituent #3: log Pow = 19.07

Retention times (test #1)

N,N-dimethylformamide, t0 = 0.346 min

DDT = 1.858 min

KY-EU = 1.700 min (1st peak), 2.188 min (2nd peak)

Confirmation of peak identity (result test #2)

- The obtained peak pattern was similar to the one provided by the Sponsor

- The retention time of DDT (5.865 min) was close to the retention time of the 1st major large peak originating from the test substance (5.649)

Conclusions:
The Competent Authority of France concluded in 2003 that the log Kow of the substance is ≥6 at 26°C.

Description of key information

The log Kow of the substance is ≥6 at 26°C.

Key value for chemical safety assessment

Log Kow (Log Pow):
6
at the temperature of:
26 °C

Additional information

The Competent Authority of France concluded in 2003 that the log Kow of the substance is ≥6 at 26°C.