Registration Dossier

Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1967
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate
EC Number:
213-551-9
EC Name:
Diethyl [[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate
Cas Number:
976-56-7
Molecular formula:
C19H33O4P
IUPAC Name:
diethyl [(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]phosphonate

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: young adult animals
- Weight at study initiation: about 3 kg
- Housing: single housing
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: at least 7 days

Test system

Type of coverage:
occlusive
Preparation of test site:
other: one test site on each animal shaved, the other test site shaved and abraded
Vehicle:
water
Controls:
not required
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 0.5 g
- Concentration: 0.5 g test substance moistened with 0.5 mL of water

VEHICLE
- Amount applied: 0.5 mL water
Duration of treatment / exposure:
24 h
Observation period:
72 h
Number of animals:
4 (2 males and 2 females)
Details on study design:
TEST SITE
- Area of exposure: 2.5 cm * 2.5 cm each of the two application sites

- Type of wrap if used: Gauze patches containing test material were secured by thin strips of adhesive tape, the entire trunk was wrapped with impervious plastic sheeting securely taped in place.

SCORING SYSTEM: according to Draize

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24 h / 72 h
Score:
0
Max. score:
4
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24 h / 72 h
Score:
0
Max. score:
4
Irritant / corrosive response data:
No dermal reactions at any timepoint.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met