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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1950

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Zirconium dinitrate oxide
EC Number:
237-529-3
EC Name:
Zirconium dinitrate oxide
Cas Number:
13826-66-9
Molecular formula:
N2O7Zr
IUPAC Name:
zirconium dinitrate oxide
Test material form:
solid - liquid: aqueous solution
Details on test material:
- Name of test material (as cited in study report): zirconyl nitrate
- 50% aqueous solution was used

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: adult rats
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: maintained in air-conditioned rooms
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
water
Details on exposure:
50% aqueous solutions were used
Doses:
single dose, no more data
No. of animals per sex per dose:
22 rats in total
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10 days

Statistics:
The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
1 250 mg/kg bw
Based on:
test mat.
Mortality:
The rats showed a progressive depression and decrease in activity until death occurred. The toxicity was considerably greater when zirconyl nitrate was administered intraperitoneally compared to the oral gavage route.
Clinical signs:
No characteristic physiologic changes were observed.
Body weight:
No characteristic physiologic changes were observed.
Gross pathology:
No characteristic gross pathologic changes were observed.

Applicant's summary and conclusion

Conclusions:
The acute LD50 value for zirconyl nitrate (50% aqueous solution) via the intraperitoneal route in rats is 1250 mg/kg bw (test item-based).

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